Swine in Biomedical Research Conference 2014, Challenges and Opportunities

2014 年猪生物医学研究会议，挑战与机遇

• 批准号: 8710842
• 负责人: Jorge A Piedrahita
• 金额: $ 1万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-20 至 2015-03-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8710842
• 关键词: Address; Animal Model; Animals; Area; Behavior; Biomedical Engineering; Biomedical Research; Cardiovascular Diseases; Categories; Clinical; Cognition Disorders; Communities; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnosis; Discipline; Disease; Family suidae; Funding; Genes; Genetic; Health; Housing; Immunology; Individual; Information Technology; Investigation; Joints; Lead; Life Style; Methodology; Modeling; Orthopedics; Pathway interactions; Physiology; Protocols documentation; Regenerative Medicine; Research; Research Personnel; Resources; Rodent Model; Science; Scientist; Series; Targeted Research; Technology; Transcend; Transgenic Organisms; Transplantation; United States National Institutes of Health; Work; base; human disease; improved; induced pluripotent stem cell; next generation sequencing; novel strategies; nutrition; pig genome; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): The Swine in Biomedical Research Conference 2014 will highlight the growing utility of swine models in biomedical research. In the toolbox category, gene-editing technologies based on meganucleases (ZFN, TALENs, CRISP/Cas), induced pluripotent stem cells, and next generation sequencing are just beginning to be appreciated. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are warranted in zoonotic diseases, cognitive behavior, bioengineering and regenerative medicine. The pig genome has been completed and sequence information can be used to construct models to development new means of diagnosing and treating life style-related diseases. The ability to genetically modify and clone pigs further enhances the value of the pig for dissecting disease mechanisms and validating clinical therapies. Both the NIH and the USDA have recognized the need for more research in this area and have either partnered to provide funding through the Dual Purpose with Dual Benefit Program (PAR-10-276), or have announced new FOA focused on improving animal models for biomedical research, including swine (PAR-13-114). There is, however, a need to further stimulate acceptance of these models by the biomedical community, as well as to increase the interactions between clinical and non-clinical scientists. Hence, this conference has been organized to directly address these acknowledged limitations. First, the Organizing Committee has selected individuals whose research has successfully transcended both health and animal science cultures, and clinical non-clinical barriers. Second, the invited speakers will showcase investigations using the pig that demonstrate successful applications as well as promising areas that require engagement across the proposed cultural divide. Finally, we will invite USDA and NIH representations to lead discussions on integrating respective strengths into addressing critical biomedical research issues.

描述（由申请人提供）：2014年生物医学研究会议将突出猪模型在生物医学研究中的日益增长的效用。在工具箱类别中，