Structure and Function Granulocyte Antigens

粒细胞抗原在细胞功能中起重要作用，包括黏附、细胞激活和免疫球蛋白的结合。这些研究的目的是更好地确定中性粒细胞抗原变异的分子基础及其在中性粒细胞功能中的作用。针对粒细胞抗原的抗体在输血反应中的作用也在调查中。 在怀孕期间或输血后，人们有时会针对粒细胞或中性粒细胞表达的抗原产生抗体。当献血者产生抗中性粒细胞特异性抗体或人类白细胞抗原时，这些抗体的不慎输注与输血反应有关。然而，并不是所有服用了中性粒细胞或人类白细胞抗原抗体的血液制品的患者都会发生输血反应，而且输血反应的类型因个体而异。目前正在研究针对白细胞的抗体在输血反应中的作用。

Granulocyte antigens play an important role in cell function including adhesion, cell activation, and binding of immunoglobulins. The purpose of these studies is to better define the molecular basis of variations in neutrophil antigens and their role in neutrophil function. The role of antibodies specific for granulocyte antigens in transfusion reactions is also being investigated. During pregnancy or following transfusion people sometimes make antibodies directed to antigens expressed by granulocytes or neutrophils. When blood donors produce antibodies to neutrophil specific or HLA antigens the inadvertent transfusion of these antibodies has been associated with transfusion reactions. However, not all patients given blood products with neutrophil or HLA antibodies experience a transfusion reaction and the type of transfusion reaction varies among individuals. Studies are underway to investigate the role of antibodies directed to leukocytes in transfusion reactions.