Structure and Function Granulocyte Antigens

粒细胞抗原的结构和功能

• 批准号: 8952804
• 负责人: David Stroncek
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8952804
• 关键词: Antibodies; Antigens; Autoantibodies; Binding; Blood donor; Cell Adhesion; Cell physiology; Cells; Goals; HLA Antigens; Host Defense; Immune response; Immunoglobulins; Individual; Isoantibodies; Leukocytes; Molecular; Patients; Play; Pregnancy; Reaction; Role; Structure; Transfusion; Variant; base; blood product; clinically relevant; defense response; experience; granulocyte; granulocyte antigens; neutrophil

Granulocyte antigens play an important role in cell function including adhesion, cell activation, and binding of immunoglobulins. The purpose of these studies is to better define the molecular basis of variations in neutrophil antigens and their role in neutrophil function. The role of antibodies specific for granulocyte antigens in transfusion reactions is also being investigated. During pregnancy or following transfusion people sometimes make antibodies directed to antigens expressed by granulocytes or neutrophils. When blood donors produce antibodies to neutrophil specific or HLA antigens the inadvertent transfusion of these antibodies has been associated with transfusion reactions. However, not all patients given blood products with neutrophil or HLA antibodies experience a transfusion reaction and the type of transfusion reaction varies among individuals. Studies are underway to investigate the role of antibodies directed to leukocytes in transfusion reactions.

粒细胞抗原在细胞功能中起重要作用，包括粘附、细胞活化和免疫球蛋白的结合。这些研究的目的是更好地确定中性粒细胞抗原变异的分子基础及其在中性粒细胞功能中的作用。粒细胞抗原特异性抗体在输血反应中的作用也正在研究中。 在怀孕期间或输血后，人们有时会产生针对粒细胞或中性粒细胞表达的抗原的抗体。当献血者产生针对中性粒细胞特异性或HLA抗原的抗体时，这些抗体的无意输血与输血反应有关。然而，并不是所有给予含有中性粒细胞或HLA抗体的血液制品的患者都会发生输血反应，并且输血反应的类型因人而异。针对白细胞的抗体在输血反应中的作用的研究正在进行中。