Differential Sensitivity Markers in Youth Drug Abuse Prevention
青少年药物滥用预防中的差异敏感性标记
基本信息
- 批准号:8868371
- 负责人:
- 金额:$ 22.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-15 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdolescentAdultAgeAlcoholsAttitudeBehaviorChild RearingChronicClientCognitionCommunicationCommunitiesCounselingDataDecision MakingDependencyDevelopmentDrug abuseDrug usageDrug userEffect Modifiers (Epidemiology)ElementsEnrollmentEnvironmentFamilyFosteringFutureGenesGoalsGrowthIndividualIndividual DifferencesInterventionLeadMarijuanaMeasuresModelingOutcomeOutcomes ResearchParentsParticipantPatient Self-ReportPatternPhysiologicalPilot ProjectsPreventive InterventionProblem SolvingProfessional counselorRandomizedRecruitment ActivityReflex actionResearchRewardsRiskRisk MarkerSchoolsSensory ProcessServicesSeveritiesStagingSubgroupSystemTeenagersTestingTherapeuticTobaccoTreatment outcomeUniversitiesVariantWorkYouthaddictionadolescent drug abuseadolescent drug usebasecostdiscountingdosagedrug abuse preventionevidence basegroup interventionhealthy lifestyleinterestintervention effectmarijuana usemarijuana usermotivational enhancement therapypersonalized carepersonalized interventionpreemptprogramspublic health relevanceresponsescaffoldskillsskills trainingsocial stigmatheoriestooltraittrend
项目摘要
DESCRIPTION (provided by applicant): The proposed R34 pilot study will conduct feasibility and exploratory intervention outcome research that will lead to the development of a personalized intervention framework for early stage adolescent drug users. The study will explore putative moderators representing two theoretically distinct frameworks and determine whether they are suitable candidates for a subsequent R01 study. One moderation framework is based on risk severity (RS) as reflected by individual differences in delay discounting (DD), a form of impulsive decision making that is positively associated with escalation to more serious levels of abuse and addiction. A second more exploratory framework is based on differential sensitivity (DS) theory. The DS framework stipulates that individuals, due to specific sensitivity factors, vary in their responsiveness to environmental influence such as the influence provided by an intervention. The study will explore DS markers associated with the reward motivational system, including dopaminergic genes, the post-auricular physiological reflex and a high sensory- processing sensitivity trait. A school-agency-university partnership will collaborate in providing services to 120 adolescents (ages 13-16) who were referred to a community counseling center because of a recent alcohol and/or marijuana incident. Recruitment will select mild/moderate drug users. Participants will be randomized to one of two evidence-based drug abuse interventions. The two interventions offer the same delivery dosage but differ in terms of their mechanism of therapeutic change (i.e., degree of environmental influence). The Teen Intervene program (TI; Winters and Leitten, 2007) is a youth-focused intervention that uses motivational interviewing, goal setting, and skills training to foster the internal development of responsible decision-making with the goal of choosing attitudes and behaviors that are healthier alternatives to drug use behaviors. The Everyday Parenting program (EP; Dishion et al., 2003; 2010) is a family focused-intervention that works with parents to provide environmental scaffolding necessary to help teens gradually internalize decision-making skills that reinforce and promote healthy lifestyle alternatives to drug use. From a risk severity perspective, we anticipate individual differences in DD will account for a moderate amount of variance in intervention response with youth scoring as steep discounters requiring the more comprehensive EP to show treatment gains. We anticipate that individuals with high sensitivity values in one or all DS factors will show positive intervention effects whether randomized to either TI or EP, owing to the assumption that both TI and EP provide sufficient intervention impact for high DS youth. In contrast, youth scoring low in sensitivity factors will require the more environmentally enriched EP to show similar benefits. The aims of this R34 are to (1) assess feasibility of recruiting, assessing, and following-up enrolled youth in an intervention tril, (2) assess the ability of staff to implement TI and EP with fidelity, and (3) obtain promising data
on moderator and outcome variables that will help answer the question of "what intervention works best for which youth" in a subsequent R01 study.
描述(由申请人提供):拟议的R34试点研究将进行可行性和探索性干预结果研究,从而为早期青少年吸毒者制定个性化干预框架。该研究将探讨代表两个理论上不同的框架的假定主持人,并确定他们是否是后续R 01研究的合适候选人。一个适度框架是基于风险严重性(RS),这反映在延迟折扣(DD)的个体差异上,这是一种冲动决策的形式,与更严重的滥用和成瘾水平呈正相关。第二个更具探索性的框架是基于微分灵敏度(DS)理论。DS框架规定,由于特定的敏感性因素,个人对环境影响(如干预措施提供的影响)的反应各不相同。本研究将探讨与奖赏动机系统相关的DS标记物,包括多巴胺能基因、耳后生理反射和高感觉加工敏感性特征。一个学校-机构-大学伙伴关系将合作为120名青少年(13-16岁)提供服务,这些青少年因最近的酒精和/或大麻事件而被转介到社区咨询中心。招募将选择轻度/中度吸毒者。参与者将被随机分配到两种基于证据的药物滥用干预措施之一。这两种干预提供相同的递送剂量,但在它们的治疗变化机制方面不同(即,环境影响程度)。青少年干预计划(TI; Winters和Leitten,2007)是一项以青少年为重点的干预措施,使用动机访谈,目标设定和技能培训来促进负责任决策的内部发展,目标是选择更健康的态度和行为来替代药物使用行为。日常育儿计划(EP; Dishion等人,二○ ○三年; 2010年)是一项以家庭为重点的干预措施,与父母合作,提供必要的环境支架,帮助青少年逐步内化决策技能,加强和促进健康的生活方式,以替代吸毒。从风险严重程度的角度来看,我们预计DD的个体差异将解释干预反应的适度差异,青年评分为陡峭的折扣,需要更全面的EP来显示治疗收益。我们预计,在一个或所有DS因素中具有高敏感性值的个体将显示出积极的干预效果,无论是随机分配到TI还是EP,因为假设TI和EP都为高DS青年提供了足够的干预影响。相比之下,在敏感性因素中得分较低的年轻人将需要更环保的EP来显示类似的益处。该R34的目的是(1)评估招募、评估和随访参与干预试验的青年的可行性,(2)评估工作人员忠实实施TI和EP的能力,以及(3)获得有希望的数据
在随后的R 01研究中,这将有助于回答“哪种干预措施最适合哪种青少年”的问题。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GERALD J AUGUST其他文献
GERALD J AUGUST的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GERALD J AUGUST', 18)}}的其他基金
Differential Sensitivity Markers in Youth Drug Abuse Prevention
青少年药物滥用预防中的差异敏感性标记
- 批准号:
9279098 - 财政年份:2015
- 资助金额:
$ 22.8万 - 项目类别:
Differential Sensitivity Markers in Youth Drug Abuse Prevention
青少年药物滥用预防中的差异敏感性标记
- 批准号:
9110930 - 财政年份:2015
- 资助金额:
$ 22.8万 - 项目类别:
Adaptive Intervention Strategies in Conduct Problems Prevention
预防行为问题的适应性干预策略
- 批准号:
8827851 - 财政年份:2013
- 资助金额:
$ 22.8万 - 项目类别:
Adaptive Intervention Strategies in Conduct Problems Prevention
预防行为问题的适应性干预策略
- 批准号:
8503315 - 财政年份:2013
- 资助金额:
$ 22.8万 - 项目类别:
DCISR for Adaptive Intervention Models in Children's Mental Health
DCISR 儿童心理健康适应性干预模型
- 批准号:
8507801 - 财政年份:2010
- 资助金额:
$ 22.8万 - 项目类别:
DCISR for Adaptive Intervention Models in Children's Mental Health
DCISR 儿童心理健康适应性干预模型
- 批准号:
8302408 - 财政年份:2010
- 资助金额:
$ 22.8万 - 项目类别:
DCISR for Adaptive Intervention Models in Children's Mental Health
DCISR 儿童心理健康适应性干预模型
- 批准号:
8715855 - 财政年份:2010
- 资助金额:
$ 22.8万 - 项目类别:
相似海外基金
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
- 批准号:
10755168 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
- 批准号:
480840 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
- 批准号:
10678157 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
- 批准号:
10744412 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
- 批准号:
23K07305 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
- 批准号:
23H02874 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Effects of adolescent social isolation on adult decision making and corticostriatal circuitry
青少年社会隔离对成人决策和皮质纹状体回路的影响
- 批准号:
10756652 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Adolescent trauma produces enduring disruptions in sleep architecture that lead to increased risk for adult mental illness
青少年创伤会对睡眠结构产生持久的破坏,从而导致成人精神疾病的风险增加
- 批准号:
10730872 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别:
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
- 批准号:
10650648 - 财政年份:2023
- 资助金额:
$ 22.8万 - 项目类别: