DCISR for Adaptive Intervention Models in Children's Mental Health

这个发展中的干预和/或服务研究中心（DCISR）将发展能力，以支持由明尼苏达大学的发展科学和预防科学研究人员和社区领导人组成的创新合作伙伴关系，这些人代表了为服务不足的城市人口的儿童心理健康服务的护理系统网络。这一社区学术合作伙伴关系将推进一个转化研究项目，为有行为障碍和相关精神共病风险的儿童和青少年提供基于证据的预防干预措施的适应性模型设计。该中心的使命是通过开发个性化决策技术，利用客户需求和偏好的经验数据来定制干预措施，改善针对不同消费者群体的循证方案的实施。数据中心的科学目标是：(1)确定裁剪变量和相应的测量工具，这些变量和工具将用于调整基于证据的计划，使其在现实世界的实践中更容易被接受和有效；(2)开展实用干预试验，为自适应干预模型的设计提供决策规则和决策辅助工具的构建信息；(3)进行验证性随机对照试验，评估适应性干预模式相对于循证项目标准模式的有效性。基础设施和能力建设的目标是：(1)充分发展支持适应性干预科学综合方案的四个DC核心；(2)在社区利益相关者的环境中注入科学探究文化，促进对干预措施的设计、部署和评估达成共识；(3)制定教育和培训计划，为下一代预防和社区心理健康科学家提供机会。提出了两个发展项目，以产生试点数据，为今后更明确的调查设计提供信息。发展研究#1将采用一项实用的干预试验，使用SMART设计来得出决策规则，这些规则将为在城市小学就读的高危儿童的早期针对性行为障碍预防计划的适应提供信息。发展研究#2将采用随机偏好试验来阐明影响家庭决定从五种干预方案中选择一种以青少年为目标的行为障碍预防计划的因素。本中心进行的研究将确定供应商和消费者的选择如何影响有效的消费者参与和预防项目的结果。积累的大量工作将指导规划用户根据其具体需求、人群和环境定制基于证据的规划。

This Developing Center for Intervention and/or Services Research (DCISR) will develop capacity to support an innovative collaborative partnership comprised of developmental science and prevention science investigators at the University of Minnesota and community leaders representing a network of systems of care serving children's mental health in underserved urban populations. This community-academic partnership will advance a program of translational research to inform the design of adaptive models of evidence-based preventive interventions for children and youth at-risk for conduct disorder and associated psychiatric comorbidities. The mission of the DC is to improve implementation of evidence-based programs to diverse consumer populations through the development of personalized decision-making technology that uses empirical data on the needs and preferences of clients to tailor interventions. The scientific aims of the DC are to: (1) identify tailoring variables and corresponding measurement tools that will be used to adapt an evidence-based program to make it more acceptable and effective in real-world practice; (2) conduct pragmatic intervention trials to inform the construction of decision rules and decision aids for design of adaptive intervention models; and (3) conduct confirmatory randomized controlled trials to evaluate the effectiveness of adaptive intervention models relative to standard models of the evidence-based programs. Infrastructure and capacity-building aims are to: (1) fully develop four DC cores that support an integrative program of adaptive intervention science; (2) infuse of culture of scientific inquiry into the settings of community stakeholders that fosters consensus about where interventions are designed, deployed, and evaluated; and (3) develop an education and training program that fosters opportunities for the next generation of prevention and community mental health scientists. Two developmental projects are proposed to generate pilot data that will inform the design of future more definitive investigations. Developmental Study #1 will employ a pragmatic intervention trial using a SMART design to derive decision rules that will inform adaptation of an early-age targeted conduct disorders prevention program for high-risk children attending urban elementary schools. Developmental Study #2 will employ a randomized preference trial to elucidate factors that influence family decisions to select one of five intervention options for an adolescent-targeted conduct disorder prevention program. The research conducted by this DC will determine how provider and consumer choices impact effective consumer engagement and outcomes in prevention programs. The accumulated body of work will guide program users in tailoring evidence-based programs for their specific needs, populations, and settings.