Coordinating Center for the Breast Cancer and the Environment Research Program

 描述（由申请人提供）：迫切需要提高我们预防乳腺癌的能力。一个对降低乳腺癌风险有很大希望的研究领域涉及提高我们对环境因素影响的认识，特别是当这些因素在乳房特别容易受到最终导致癌症的变化的影响时。拟议的乳腺癌和环境研究计划协调中心（BCERP）联盟将支持以下国家建议的研究，以优先预防，使用跨学科研究方法，并加强对可能影响乳腺癌风险的化学和物理因素的研究。我们的总体目标是支持综合科学研究，以提高我们对整个生命周期中乳腺癌风险的环境和遗传因素的理解，特别关注易感性窗口。具体目标是：1-通过确定促进跨项目跨学科互动的机会，标准化和整合研究工作，并最大限度地利用资源，在团队科学中提供领导; 2-为联盟提供特殊的协调，包括定义共同的愿景和使命，确定共享资源，制定标准政策，管理机会基金以分发给联盟成员，协助NIH工作人员，支持指导委员会、工作组和年度科学会议; 3-利用BCERP成员之间的数据和其他资源共享; 4.支持跨项目交流以及向不同的合作伙伴和受众传播研究结果，包括更广泛的乳腺癌和环境科学研究界，支持下一代乳腺癌研究人员的培训和指导;以及5-促进内部和外部评估，以最大限度地提高协调中心和联盟的绩效，跨学科性质，生产力和有效性。我们的使命是通过识别和促进跨BCERP合作的机会，并通过与利益相关者的伙伴关系传播研究成果，为BCERP联盟提供知识领导和后勤支持。我们的多学科团队包括乳腺癌流行病学，基础科学，环境健康，毒理学，项目评估，生物统计学，外展/社区参与和研究管理方面的专家，以及指导和培训。威斯康星州Carbone癌症中心的大学提供了支持协调中心的理想环境，由于其多种资源和强大的建立与地方，区域和国家的研究和宣传组织的关系。BCERP协调中心将采用多种创新方法，利用联盟成员的共同热情，阐明环境因素在易感性窗口期间增加乳腺癌风险的作用，提供合作机会，并使BCERP能够大幅减少这种常见疾病的负担。

 DESCRIPTION (provided by applicant): The critical need remains to improve our ability to prevent breast cancer. An area of research that holds great promise for reducing breast cancer risk concerns improving our knowledge of the impact of environmental factors, especially when these factors appear to act when the breast is particularly susceptible to changes that ultimately lead to cancer. The proposed Coordinating Center for the Breast Cancer and the Environment Research Program (BCERP) consortium will support research that follows national recommendations to prioritize prevention, use transdisciplinary research approaches, and intensify the study of chemical and physical factors that potentially influence the risk of developing breast cancer. Our overarching goal is to support integrated scientific research to enhance our understanding of environmental and genetic factors underlying breast cancer risk throughout the lifespan, with particular focus on windows of susceptibility. Specific Aims are: 1- to provide leadership in team science by identifying opportunities to facilitate cross- project transdisciplinary interaction, standardize and integrate research efforts, and maximize use of resources; 2- to provide exceptional coordination for the consortium including defining a shared vision and mission, identifying shared resources, developing standard policies, managing Opportunity Funds to distribute to Consortium members, assisting NIH staff, and supporting a Steering Committee, Working Groups, and an annual scientific meeting; 3- to leverage sharing of data and other resources among BCERP members; 4- to support cross-project communication as well as dissemination of findings to diverse partners and audiences including the broader breast cancer and environmental science research communities, and to support the training and mentoring of the next generation of breast cancer researchers; and 5- to facilitate internal and external evaluation to maximize the Coordinating Center's and Consortium's performance, transdisciplinary nature, productivity and effectiveness. Our mission is to provide intellectual leadership and logistical support for the BCERP consortium by identifying and facilitating opportunities for cross-BCERP collaboration, and disseminating research findings through partnerships with stakeholders. Our multidisciplinary team includes experts in breast cancer epidemiology, basic science, environmental health, toxicology, program evaluation, biostatistics, outreach/community engagement, and research administration, as well as mentoring and training. The University of Wisconsin Carbone Cancer Center provides the ideal environment for supporting the Coordinating Center due to its multiple resources and strong established relationships with local, regional, and national research and advocacy organizations. The BCERP Coordinating Center will use multiple innovative approaches to leverage Consortium members' common passion for elucidating the role of environmental factors that act during windows of susceptibility to increase risk of breast cancer, provide opportunities for collaboration, and enable BCERP to bring about substantive reductions in the burden of this common disease.