Investigation of a New Approach to Regulate Fibrin Clot Retraction and Arterial Thrombolysis

通过给予凝块溶解药物（纤维蛋白溶解剂）清除患者体内的病理性血凝块。然而，这些药物往往是无效的，并导致出血。我们已经确定了一个新的血小板介导的途径控制血液凝块的收缩，凝块稳定性的重要。在这个提议中，我们将研究这一途径的抑制剂松动血凝块的潜力，并促进纤维蛋白溶解剂的作用，以促进凝块溶解。

Pathological blood clots are removed in patients by administering clot dissolving drugs (fibrinolytics). However these drugs are quite often ineffective and cause bleeding. We have identified a new platelet-mediated pathway controlling contraction of blood clots, important for clot stability. In this proposal, we will examine the potential for inhibitors of this pathway to loosen blood clots, and facilitate the actions of fibrinolytics to promote clot dissolution.