Investigation of Neuregulin precessing by beta-site APP cleaving enzyme and gamma secretase in schizophrenia

精神分裂症（SCZ）是一种复杂的精神障碍，出现在成年前后的男性和女性中。到目前为止，还没有明确的病理症状来识别SCZ个体并将其归入特定的群体。一些蛋白质在基因上与这种疾病有关。我将研究其中一些蛋白质是如何干扰人类大脑功能的。我最近发表的数据显示，SCZ组大脑中的一种蛋白质减少。我的项目可能有助于开发出副作用更小、更有选择性的新疗法。

Schizophrenia (SCZ) is a complex psychiatric disorder that appears in male and female around adulthood. To date there is no clear pathological symptoms to identify SCZ individuals and place them in a specific group. Some proteins are genetically associated with this disease. I will investigate how some of these proteins disturb the function of the brain in human. My recent published data shows decrease of one of the proteins in the brain of SCZ group. My project may help develop novel and more selective therapies with less side-effects.