FASEB SRC on Protein Lipidation, Signaling and Membrane Domains.

FASEB SRC 关于蛋白质脂化、信号传导和膜结构域。

• 批准号: 8977960
• 负责人: CHRISTINE A HRYCYNA
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8977960
• 关键词: Affect; Alzheimer' s Disease; American; Area; Award; Biochemistry; Biology; Biophysics; Cancer Biology; Cell physiology; Cellular biology; Clinical Medicine; Collaborations; Differentiation and Growth; Disease; Ensure; Equilibrium; Event; Exhibits; Fostering; Funding; Genetic; Lipids; Malignant Neoplasms; Membrane; Membrane Microdomains; Membrane Protein Traffic; Minority Groups; Obesity; Oral; Participant; Postdoctoral Fellow; Premature aging syndrome; Process; Proteins; Qualifying; Research; Research Personnel; Rivers; Role; Signal Transduction; Signaling Protein; Site; Societies; Training; Travel; Underrepresented Minority; Vermont; Woman; Work; abstracting; career development; cohort; drug discovery; effective therapy; graduate student; human disease; meetings; membrane synthesis; next generation; posters; public health relevance; symposium; trafficking

 DESCRIPTION (provided by applicant): The field of protein lipidation, signaling and membrane domains is an extremely active area of research as investigators seek to refine and expand our understanding of the consequences of protein-lipid interactions for cell signaling, growth and differentiation, and membrane synthesis and trafficking, and the role of these processes in human disease. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on "Protein Lipidation, Signaling and Membrane Domains", that will be held from July 19-24, 2015 in Saxtons River, Vermont. This meeting will highlight recent progress and provide a forum for critical discussions on these topics and promote interactions, idea-sharing, and collaborations between internationally leading researchers from diverse fields ranging from biophysics and biochemistry to cancer biology, genetics, clinical medicine and drug discovery. Lipid-modified proteins, signaling, and membrane domains represent distinct areas of research that are nonetheless closely intertwined. For example, many lipidated proteins regulate membrane synthesis and vesicular trafficking and intra- and inter- cellular signaling events. Moreover, lipidated proteins exhibit a strong yet dynamic interaction with membranes and their interaction with effector molecules and downstream signaling partners can be affected by shuttling in and out of membrane microdomains. Thus, investigators in these research areas benefit from and find synergy in discussions and collaborations initiated at this meeting. An equally important function of the meeting is to stimulate meaningful interactions between trainees including graduate students and postdoctoral fellows and established leaders in these fields. This objective is realistic given the small size of the conference (maximum 200 participants) and the requirement that speakers remain on-site throughout the meeting. We are also committed to fostering the career development of trainees. To this end, speakers chosen from submitted abstracts will present fifteen short talks, with at least two-thirds selected from this cohort. Furthermore, we propose to offer 20 travel awards of $500 to highly qualified graduate students and postdoctoral fellows and give a select group of them the opportunity to summarize the rationale, results, and importance of the work presented in their poster in a 2-minute oral presentation. In the selection process, we will ensure that the sessions are balanced with regard to the inclusion of women and underrepresented minority groups.

 描述（由申请人提供）：蛋白质脂质化、信号传导和膜结构域领域是一个非常活跃的研究领域，因为研究人员试图完善和扩展我们对蛋白质-脂质相互作用对细胞信号传导、生长和分化、膜合成和运输的后果以及这些过程在人类疾病中的作用的理解。我们请求资金部分支持美国实验生物学学会联合会（FASEB）关于“蛋白质脂质化，信号传导和膜结构域”的会议，该会议将于2015年7月19日至24日在佛蒙特州的萨克顿河举行。本次会议将突出最近的进展，并为这些主题的关键讨论提供一个论坛，并促进来自生物物理学和生物化学，癌症生物学，遗传学，临床医学和药物发现等不同领域的国际领先研究人员之间的互动，思想分享和合作。脂质修饰的蛋白质，信号传导和膜结构域代表了不同的研究领域，但这些领域却紧密交织在一起。例如，许多脂化蛋白调节膜合成和囊泡运输以及细胞内和细胞间信号传导事件。此外，脂化蛋白质表现出 与膜的强而动态的相互作用以及它们与效应分子和下游信号传导配偶体的相互作用可受到穿梭进出膜微区的影响。因此，这些研究领域的研究人员从这次会议上发起的讨论和合作中受益并找到协同作用。 会议的一个同样重要的功能是促进包括研究生和博士后研究员在内的受训人员与这些领域的知名领导人之间进行有意义的互动。这一目标是现实的， 会议规模小（最多200名与会者），要求发言者在整个会议期间留在现场。我们亦致力促进学员的职业发展。为此，从提交的摘要中选择的演讲者将进行15次简短的演讲，其中至少三分之二来自这一组。此外，我们建议 为高素质的研究生和博士后研究员提供20个500美元的旅行奖励，并让他们中的一组有机会在2分钟的口头报告中总结他们海报中提出的工作的原理，结果和重要性。在甄选过程中，我们将确保各届会议在妇女和代表性不足的少数群体的参与方面保持平衡。