FASEB SRC on Protein Lipidation, Signaling and Membrane Domains
FASEB SRC 关于蛋白质脂化、信号传导和膜结构域
基本信息
- 批准号:8203842
- 负责人:
- 金额:$ 0.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-06 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAmericanAreaAwardBiochemistryBiologyBiophysicsCancer BiologyCell physiologyCellular biologyClinical MedicineCollaborationsCommitDifferentiation and GrowthDiseaseEnsureEquilibriumExhibitsFosteringFundingGeneticLipidsMalignant NeoplasmsMembraneMembrane MicrodomainsMembrane Protein TrafficMinority GroupsOralParticipantPostdoctoral FellowProcessProteinsQualifyingResearchResearch PersonnelRiversRoleSignal TransductionSignaling ProteinSiteSocietiesTravelUnderrepresented MinorityVermontWomanWorkabstractingcareer developmentcohorteffective therapygraduate studenthuman diseasemeetingsmembrane synthesisposterssymposiumtrafficking
项目摘要
DESCRIPTION (provided by applicant): The field of protein lipidation, signaling and membrane domains is an extremely active area of research as investigators seek to refine and expand our understanding of the consequences of protein-lipid interactions for cell signaling, growth and differentiation, and membrane synthesis and trafficking, and the role of these processes in human disease. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on "Protein Lipidation, Signaling and Membrane Domains", that will be held from July 24-29, 2011 in Saxtons River, Vermont. This meeting will highlight recent progress and provide a forum for critical discussions on these topics and promote interactions, idea-sharing, and collaborations between researchers from diverse fields ranging from biophysics and biochemistry to cancer biology, genetics, and clinical medicine. Lipid-modified proteins, signaling, and membrane domains represent distinct areas of research that are nonetheless closely intertwined. For example, many lipidated proteins regulate membrane synthesis and vesicular trafficking. Moreover, lipidated proteins exhibit a strong yet dynamic interaction with membranes and their interaction with effector molecules and downstream signaling partners can be affected by shuttling in and out of membrane microdomains. Thus, investigators in these research areas benefit from and find synergy in discussions and collaborations initiated at this meeting. An equally important function of the meeting is to stimulate meaningful interactions between trainees including graduate students and postdoctoral fellows and established leaders in these fields. This objective is realistic given the small size of the conference (maximum 200 participants) and the requirement that speakers remain on-site throughout the meeting. We are also committed to fostering the career development of trainees. To this end, speakers chosen from submitted abstracts will present seventeen short talks, with at least two-thirds selected from this cohort. Furthermore, we propose to offer 25 travel awards of $500 to highly qualified graduate students and postdoctoral fellows and give them each the opportunity to summarize the rationale, results, and importance of the work presented in their poster in a 5-minute oral presentation during the first poster session. In the selection process, we will ensure that the sessions are balanced with regard to the inclusion of women and underrepresented minority groups.
PUBLIC HEALTH RELEVANCE: We are requesting partial support for our scientific conference entitled "Protein Lipidation, Signaling and Membrane Domains", that will be held from July 24-29, 2011 in Saxtons River, Vermont. These research fields have emerged as important and integrated facets in the study of basic cellular biology and many human diseases, including cancer. It is essential to bring together researchers from these fields to share findings, exchange ideas, and initiate collaborations in order to better understand the biology of these cellular processes and develop effective treatments for diseases such as cancer.
描述(由申请人提供):蛋白质脂质化、信号传导和膜结构域领域是一个非常活跃的研究领域,因为研究人员试图完善和扩展我们对蛋白质-脂质相互作用对细胞信号传导、生长和分化、膜合成和运输的后果以及这些过程在人类疾病中的作用的理解。我们请求资金部分支持美国实验生物学学会联合会(FASEB)关于“蛋白质脂质化,信号传导和膜结构域”的会议,该会议将于2011年7月24日至29日在佛蒙特州的萨克顿河举行。本次会议将突出最新进展,并为这些主题的关键讨论提供一个论坛,并促进来自生物物理学和生物化学,癌症生物学,遗传学和临床医学等不同领域的研究人员之间的互动,思想分享和合作。脂质修饰的蛋白质,信号传导和膜结构域代表了不同的研究领域,但这些领域却紧密交织在一起。例如,许多脂化蛋白调节膜合成和囊泡运输。此外,脂化蛋白质表现出与膜的强而动态的相互作用,并且它们与效应分子和下游信号传导伴侣的相互作用可以受到穿梭进出膜微结构域的影响。因此,这些研究领域的研究人员从这次会议上发起的讨论和合作中受益并找到协同作用。 会议的一个同样重要的功能是促进包括研究生和博士后研究员在内的受训人员与这些领域的知名领导人之间进行有意义的互动。鉴于会议规模较小(最多200名与会者),而且要求发言者在整个会议期间留在现场,这一目标是现实的。我们亦致力促进学员的职业发展。为此,从提交的摘要中选择的演讲者将进行17次简短的演讲,其中至少三分之二来自这一组。此外,我们建议为高素质的研究生和博士后研究员提供25个500美元的旅行奖励,并让他们有机会在第一次海报会议期间以5分钟的口头报告总结海报中所提出的工作的原理,结果和重要性。在选拔过程中,我们将确保会议在纳入妇女和代表性不足的少数群体方面保持平衡。
公共卫生相关性:我们正在请求部分支持我们的科学会议题为“蛋白质脂质化,信号转导和膜结构域”,将于2011年7月24日至29日在萨克顿河,佛蒙特州举行。这些研究领域已经成为基础细胞生物学和许多人类疾病(包括癌症)研究的重要和综合方面。必须将这些领域的研究人员聚集在一起,分享发现,交流思想,并开展合作,以便更好地了解这些细胞过程的生物学,并开发有效的治疗方法,如癌症。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors.
- DOI:10.20517/cdr.2021.19
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Goebel J;Chmielewski J;Hrycyna CA
- 通讯作者:Hrycyna CA
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHRISTINE A HRYCYNA其他文献
CHRISTINE A HRYCYNA的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHRISTINE A HRYCYNA', 18)}}的其他基金
FASEB SRC on Protein Lipidation, Signaling and Membrane Domains.
FASEB SRC 关于蛋白质脂化、信号传导和膜结构域。
- 批准号:
8977960 - 财政年份:2015
- 资助金额:
$ 0.4万 - 项目类别:
Structure, Function and Conformational Dynamics of the Ste14p Methyltransferase
Ste14p 甲基转移酶的结构、功能和构象动力学
- 批准号:
8483309 - 财政年份:2013
- 资助金额:
$ 0.4万 - 项目类别:
Structure, Function and Conformational Dynamics of the Ste14p Methyltransferase
Ste14p 甲基转移酶的结构、功能和构象动力学
- 批准号:
9040994 - 财政年份:2013
- 资助金额:
$ 0.4万 - 项目类别:
Structure, Function and Conformational Dynamics of the Ste14p Methyltransferase
Ste14p 甲基转移酶的结构、功能和构象动力学
- 批准号:
8675864 - 财政年份:2013
- 资助金额:
$ 0.4万 - 项目类别:
Modulating P-glycoprotein to Enhance Neurodegenerative Drug Penetration of Brain
调节 P-糖蛋白增强神经退行性药物在大脑中的渗透
- 批准号:
7489886 - 财政年份:2007
- 资助金额:
$ 0.4万 - 项目类别:
Modulating P-glycoprotein to Enhance Neurodegenerative Drug Penetration of Brain
调节 P-糖蛋白增强神经退行性药物在大脑中的渗透
- 批准号:
7329774 - 财政年份:2007
- 资助金额:
$ 0.4万 - 项目类别:
相似海外基金
Asian American Community Cohort of the New York Metropolitan Area
纽约都会区亚裔美国人社区群体
- 批准号:
10724342 - 财政年份:2023
- 资助金额:
$ 0.4万 - 项目类别:
Individual, cultural, and area-based factors associated with survivorship care among Asian/Asian American childhood cancer survivors
与亚裔/亚裔美国儿童癌症幸存者的生存护理相关的个人、文化和地区因素
- 批准号:
10693965 - 财政年份:2021
- 资助金额:
$ 0.4万 - 项目类别:
Individual, cultural, and area-based factors associated with survivorship care among Asian/Asian American childhood cancer survivors
与亚裔/亚裔美国儿童癌症幸存者的生存护理相关的个人、文化和地区因素
- 批准号:
10482384 - 财政年份:2021
- 资助金额:
$ 0.4万 - 项目类别:
Individual, cultural, and area-based factors associated with survivorship care among Asian/Asian American childhood cancer survivors
与亚裔/亚裔美国儿童癌症幸存者的生存护理相关的个人、文化和地区因素
- 批准号:
10275095 - 财政年份:2021
- 资助金额:
$ 0.4万 - 项目类别:
Adaptation of the US-American pediatric Patient-Reported Outcome Measurement Information System (PROMIS) for the German speaking area
美国儿科患者报告结果测量信息系统 (PROMIS) 适应德语地区
- 批准号:
271504683 - 财政年份:2015
- 资助金额:
$ 0.4万 - 项目类别:
Research Grants
Transnationalism in American Studies and Future of Area Studies
美国研究中的跨国主义和区域研究的未来
- 批准号:
15K01898 - 财政年份:2015
- 资助金额:
$ 0.4万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Evaluating Area-Based Socioeconomic Measures from American Community Survey data
根据美国社区调查数据评估基于地区的社会经济措施
- 批准号:
8565162 - 财政年份:2012
- 资助金额:
$ 0.4万 - 项目类别:
Doctoral Dissertation Improvement Grant: Clovis Settlement Behavior in the American Southeast: Using Lithic Artifact Analysis to Evaluate the Staging-Area Model
博士论文改进补助金:美国东南部的克洛维斯定居点行为:利用石器文物分析来评估集结区模型
- 批准号:
0852946 - 财政年份:2008
- 资助金额:
$ 0.4万 - 项目类别:
Standard Grant
Inter-American materials research - Thin film materials for large area encapsulation barriers for flexible organic electronics
美洲材料研究 - 用于柔性有机电子器件大面积封装屏障的薄膜材料
- 批准号:
312945-2005 - 财政年份:2007
- 资助金额:
$ 0.4万 - 项目类别:
Special Research Opportunity Program - Inter-American Collaboration in Materials Research
Inter-American materials research - Thin film materials for large area encapsulation barriers for flexible organic electronics
美洲材料研究 - 用于柔性有机电子大面积封装屏障的薄膜材料
- 批准号:
312945-2005 - 财政年份:2006
- 资助金额:
$ 0.4万 - 项目类别:
Special Research Opportunity Program - Inter-American Collaboration in Materials Research