Strengthening Hispanic Families via NIDA Prevention Science

通过 NIDA 预防科学加强西班牙裔家庭

• 批准号: 8828158
• 负责人: Jose Ruben Parra-Cardona
• 金额: $ 17.74万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8828158
• 关键词: Acceleration; Address; Adolescent; African; African American; Age; Alcohol consumption; Alcohol or Other Drugs use; American; Applications Grants; Award; Back; Biological; Biological Assay; Child; Child Rearing; Cigarette; Collaborations; Complement; Cuban American; Data; Data Analyses; Development; Distal; Drug usage; Electronics; Empirical Research; Ensure; Environment; Epidemiology; Family; Foundations; Funding; Future; Generations; Genes; Genetic; Genetic Research; Goals; Grant; Health; Heavy Drinking; High Prevalence; Hispanics; Interdisciplinary Study; Internet; Intervention; Intervention Studies; Leadership; Learning; Life; Low income; Measurement; Mental Depression; Mentored Research Scientist Development Award; Mentors; Methodology; Mexican Americans; Michigan; Minority; Modeling; Monitor; National Institute of Drug Abuse; Oregon; Outcome; Parents; Participant; Patient Self-Report; Persons; Pharmaceutical Preparations; Pilot Projects; Population; Population Heterogeneity; Population Study; Prevalence; Prevention; Prevention Research; Prevention trial; Preventive Intervention; Publications; Puerto Rican; Randomized Controlled Trials; Reading; Reporting; Request for Applications; Research; Research Design; Research Personnel; Residencies; Risk; Ruthenium Ben; Sample Size; Sampling; School-Age Population; Science; Scientist; Senior Scientist; Site; Smoke; Specimen; Stimulus; Strategic Planning; Stress; Structure; Substance abuse problem; System; Target Populations; Technology; Testing; Time; Tobacco; Training; Underrepresented Minority; United States; United States National Institutes of Health; Youth; base; binge drinking; career; career development; college; cost; cultural values; early onset; early onset drug use; efficacy evaluation; evidence base; experience; externalizing behavior; follow-up; health disparity; high risk; intervention effect; junior high school; marijuana use; meetings; multi-site trial; prevent; programs; public health relevance; randomized trial; reduced substance use; response; simulation; skills; stressor; success; theories; therapy design; willingness

DESCRIPTION (provided by applicant): These application requests 5 years of K01 support to accelerate the NIDA-focused interdisciplinary research career development of Dr. Ruben Parra-Cardona, a clinician-researcher who seeks to become an independent NIDA prevention researcher committed to underserved Hispanic adolescents and families. His current research evaluates a cultural adaptation of an evidence-based parenting intervention for at-risk Hispanic families with young children (ages 4-11), for which there is potential distal NIDA impact such as reduced risk of starting to smoke tobacco or to use other drugs. Complete evidence on distal benefits of early randomized trial interventions of this type cannot be seen unless the scale of research shifts upward, as in multi-site trials, and unless the measurements include bio-assays to confirm self-report drug use, with probes for potential gene- intervention interactions. Based on the proposed K01 career training objectives, the applicant will acquire the necessary skills to develop an interdisciplinary program of prevention research, informed by epidemiological and biomedical science. During 75% protected time for career development toward independent R01 project leadership, core learning objectives will be met (e.g., RCR, FCOI, grants management). In addition to its core, the training plan has 5 tracks: (1) enhanced mastery of small sample parenting intervention research; (2) enhanced mastery of research design and measurements for larger sample multi-site NIDA prevention research on youth developmental trajectories leading toward NIDA outcomes; (3) enhanced mastery of data analysis for interdependent observations from multiple sites; (4) new learning about integration of biological assays in NIDA family intervention and prevention research via collaborations with expert NIH toxicologists and genetics researchers; (5) mastery of electronic technology complements to current 'in person' intervention delivery and program impact assessment. The proposed award is crucial now that the applicant has become K01-eligible via permanent residency. His college has guaranteed protected time for this K01 career acceleration through structured mentoring program led by a NIDA K05 Senior Scientist, backed by a strong local team of federally funded co-mentors, as well as scientific advisors. Through the proposed K01 award, Dr. Parra-Cardona will gain mastery of the theory and research approaches now being refined by quantitative developmental scientists in new lines of NIDA prevention research. The training plan includes guided readings, coursework, among other activities leading to publications. A prevention pilot study will serve as a 'preliminary study' for a NIDA R01 grant proposal planned for Year 4 of the proposed award. This application is responsive to NIH and NIDA's strategic plans highlighting the need to implement interdisciplinary programs of research aimed at preventing young people from ever using drugs, as well as ensuring that at-risk and underserved minority populations benefit from these scientific efforts.

描述（由申请人提供）：这些申请要求 5 年的 K01 支持，以加速 Ruben Parra-Cardona 博士以 NIDA 为重点的跨学科研究职业发展。Ruben Parra-Cardona 博士是一名临床医生兼研究员，致力于成为一名独立的 NIDA 预防研究员，致力于服务不足的西班牙裔青少年和家庭。他目前的研究评估了针对有幼儿（4-11 岁）的高危西班牙裔家庭的循证育儿干预的文化适应性，这可能会产生 NIDA 的远端影响，例如降低开始吸烟或使用其他药物的风险。除非研究规模向上移动（如多中心试验），并且除非测量包括生物测定以确认自我报告的药物使用情况，并探索潜在的基因干预相互作用，否则无法看到有关此类早期随机试验干预的最终益处的完整证据。根据拟议的 K01 职业培训目标，申请人将获得必要的技能，以流行病学和生物医学科学为基础，制定跨学科的预防研究计划。在 75% 的职业发展受保护时间内，实现独立的 R01 项目领导力，将实现核心学习目标（例如，RCR、FCOI、拨款管理）。除核心内容外，培训计划还有5个轨道：（1）加强对小样本育儿干预研究的掌握； (2) 加强对针对青年发展轨迹的大样本多地点 NIDA 预防研究的研究设计和测量的掌握，以实现 NIDA 成果； (3) 加强对多站点相互依赖观测数据分析的掌握； (4) 通过与 NIH 毒理学专家和遗传学研究人员合作，获得关于将生物检测整合到 NIDA 家庭干预和预防研究中的新知识； (5) 掌握电子技术可以补充当前的“亲自”干预实施和项目影响评估。鉴于申请人已通过永久居留权获得 K01 资格，拟议的奖励至关重要。他的学院通过由 NIDA K05 高级科学家领导的结构化指导计划，并得到由联邦资助的联合导师和科学顾问组成的强大本地团队的支持，保证了 K01 职业加速的受保护时间。通过拟定的 K01 奖项，Parra-Cardona 博士将掌握目前由定量发展科学家在 NIDA 预防研究新领域中完善的理论和研究方法。培训计划包括指导阅读、课程作业以及其他导致出版的活动。一项预防试点研究将作为 NIDA R01 拨款提案的“初步研究”，该提案计划在拟议资助的第 4 年进行。该应用程序响应 NIH 和 NIDA 的战略计划，强调需要实施跨学科研究计划，旨在防止年轻人吸毒，并确保高危和服务不足的少数群体从这些科学努力中受益。