Community hospital ID of cardiovascular risk patients during cancer

社区医院癌症期间心血管风险患者ID

• 批准号: 8905910
• 负责人: Holly Goodwin
• 金额: $ 22.48万
• 依托单位: ALBUS IMAGING LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8905910
• 关键词: Academic Medical Centers; Acute; Address; Adjuvant Chemotherapy; Algorithms; Biological Markers; Blood Tests; Breast Cancer Patient; Breast Cancer Treatment; Breast Cancer survivor; Cancer Patient; Cancer Survivor; Cardiac; Cardiotoxicity; Cardiovascular Physiology; Cardiovascular system; Clinical; Clinical Trials; Community Healthcare; Community Hospitals; Data; Deterioration; Diabetes Mellitus; Diagnosis; Double-Blind Method; Early Diagnosis; Echocardiography; Enrollment; Event; Fees; Funding; Future; Generic Drugs; Goals; Health Sciences; Heart; Heart Injuries; Heart failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Image; Image Analysis; Imaging Techniques; Individual; Injury; Intervention; Left; Left Ventricular Ejection Fraction; MRI Scans; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Methods; Modality; Modeling; Monitor; Morbidity - disease rate; Myocardial Infarction; Myocardial dysfunction; Participant; Patients; Performance; Phase; Physicians; Physiologic pulse; Placebos; Prevention; Process; Protocols documentation; Quality of life; Randomized; Randomized Clinical Trials; Regimen; Research; Research Methodology; Resources; Risk; Scanning; Schedule; Science; Sensitivity and Specificity; Serum; Services; Solutions; Staging; Statistical Models; Stratification; Stroke; System; Techniques; Technology; Testing; Time; Training; Troponin I; United States National Institutes of Health; Ventricular; Woman; Work; abstracting; atorvastatin; base; cancer therapy; cardiovascular injury; cardiovascular risk factor; cardiovascular visualization; chemotherapy; comparative effectiveness; cost; diabetic; experience; forest; health care delivery; image processing; imaging biomarker; improved; malignant breast neoplasm; new technology; personalized medicine; phase 1 study; premature; prevent; public health relevance

 DESCRIPTION (provided by applicant): Albus Imaging Community hospital identification of high CV risk patients during cancer treatment Project Summary/Abstract: The goal of this research is to enable community hospitals to detect cardiovascular injury very early in breast cancer patients using our advanced cardiac magnetic resonance imaging (MRI) procedures. This is very significant because 1) nearly 20% of breast cancer survivors will experience a serious cardiac event and 2) most of these patients are treated in community hospital settings that do not currently have access to these advanced imaging techniques. Our rapid cardiac imaging acquisition and analysis process overcomes several of the limitations that have prevented the widespread clinical utilization of cardiac MRI, including the relatively high level o training necessary to acquire and analyze the images, and the lengthy 45+ minute scan and analysis times. Introducing this technology to community hospitals will allow our company to work toward another one of its overall goals: to identify the women most susceptible to cardiac injury so they can be targeted with cardioprotective regimens to reduce cardiovascular injury and improve overall survival. Initially in this Phase I proposal, we will compare the utility of ou rapid magnetic resonance imaging (MRI) scan, analysis, and forecasting process with the more traditional techniques, such as, conventional 45-minute MRI, echocardiography, and cardiac blood tests in women receiving treatment for breast cancer in five community hospitals. If this Phase I study is successful, we will expand and test the product in women treated among 15 community hospitals nationwide. We believe that this advanced technique can be helpful and scaled for use in many other patients at risk for potential CV injury such as other cancer patients, diabetics and those with other causes of heart failure.

 描述（由申请人提供）：Albus Imaging社区医院在癌症治疗期间识别高CV风险患者项目总结/摘要：本研究的目标是使社区医院能够使用我们先进的心脏磁共振成像（MRI）程序在乳腺癌患者中早期检测心血管损伤。这是非常重要的，因为1）近20%的乳腺癌幸存者将经历严重的心脏事件，2）这些患者中的大多数在社区医院接受治疗，目前无法获得这些先进的成像技术。我们的快速心脏成像采集和分析过程克服了阻碍心脏MRI广泛临床应用的几个限制，包括采集和分析图像所需的相对高水平的培训，以及长达45分钟以上的扫描和分析时间。将这项技术引入社区医院将使我们公司能够朝着另一个总体目标努力：识别最容易受到心脏损伤的女性，以便他们能够有针对性地接受心脏保护方案，以减少心血管损伤并提高总体生存率。在第一阶段的提案中，我们将比较快速磁共振成像（MRI）扫描、分析和预测过程与传统技术的效用，例如在五家社区医院接受乳腺癌治疗的妇女中进行常规45分钟MRI、超声心动图和心脏血液检查。如果第一阶段研究成功，我们将在全国15家社区医院的妇女中扩大和测试该产品。我们认为，这种先进的技术可以帮助并扩展用于许多其他有潜在CV损伤风险的患者，如其他癌症患者，糖尿病患者和其他心力衰竭原因的患者。