The Ohio State University Pancreatic Disorders Network (OSU-PDN)
俄亥俄州立大学胰腺疾病网络 (OSU-PDN)
基本信息
- 批准号:9045208
- 负责人:
- 金额:$ 49.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-28 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:ANXA5 geneAbdominal PainAddressAdultBiological MarkersBloodBrittle diabetesCYP11B2 geneChildhoodClinicalClinical ResearchClinical SciencesCollaborationsConsultDevelopmentDiabetes MellitusDiagnosisDiagnosticDigestive System DisordersDiseaseDisease ProgressionEarly DiagnosisFibrosisFundingGastroenterologistGastroenterologyGoalsHealth Services AccessibilityIndividualInflammationInstitutionKnowledgeLeftLiquid substanceMain pancreatic ductMalignant NeoplasmsMalignant neoplasm of pancreasMalnutritionMedicalMedical ResearchMedical centerMethodsNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin-Dependent Diabetes MellitusOhioOperative Surgical ProceduresOrganPancreasPancreatic DiseasesPancreatic PolypeptideParticipantPatient TriagePatientsPediatric ResearchPerformancePrimary Care PhysicianProteinsProteomeProteomicsProtocols documentationPublishingResearchResearch InfrastructureResearch ProposalsResourcesRiskSecondary toSerumStagingTestingTranslational ResearchUnited StatesUnited States National Institutes of HealthUniversitiesUrineValidationbasecancer typechronic pancreatitiscohortpancreatic juiceprogramspublic health relevancerepositoryresearch studyresponsesample collectiontranslational study
项目摘要
DESCRIPTION (provided by applicant): The diagnosis of chronic pancreatitis and T3cDM remain two of the greatest challenges and unmet needs in modern gastroenterology. The focus of this U01 application from The Ohio State University is to form a strategic alliance among academic institutions in the United States. Our major goals are to address the research objectives and aims of the Consortium, and to be considered as a clinical center. Specifically, we a) describe The Ohio State University Pancreatic Disorders Network (OSU-PDN), b) propose two research studies for consideration by the Consortium and c) outline our clinical and translational research infrastructure. Several key experimental observations from our group in CP and T3cDM warrant confirmation [OSU- PDN] and validation [CSCPDPC-CCs] : 1) Proteomic analysis of pancreas fluid (PF) and urine (U) in CP subjects revealed statistically significant fold-changes in several pancreatic fluid proteins - SERPINA5, ANXA5, CST3 (candidate pancreatic fluid markers) and urine proteins - CPN2, A1AG1, AMYP (candidate urine markers) when compared to healthy controls and 2) A significant difference in serum pancreatic polypeptide response to a mixed meal was observed that may distinguish T3cDM from the much more prevalent T2DM. These preliminary observations are the focus of our research proposals for consideration by the Consortium Steering Committee. Our Clinical Center will be centrally coordinated by the Ohio State University Center for Clinical and Translational Science (CCTS/CTSA) in collaboration with other CTSAs from our "network partners" in the OSU-PDN and the Consortium. The CCTS/CTSA provides consulting services and access to clinical and translational research infrastructure. This unique resource will assist our team in communicating with the CDMC, DSMB and NIDDK central repository. Both research proposals from our network address gaps in knowledge and understanding of chronic pancreatitis, diabetes and pancreas cancer as outlined by the NIDDK- National Commission on Digestive Diseases, and are strategically aligned with the objectives of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC-CCs) (U01).
描述(由申请人提供):慢性胰腺炎和T3 cDM的诊断仍然是现代胃肠病学中两个最大的挑战和未满足的需求。本次俄亥俄州州立大学U 01申请的重点是在美国学术机构之间形成战略联盟。我们的主要目标是解决研究目标和联盟的目标,并被视为一个临床中心。具体而言,我们a)描述了俄亥俄州州立大学胰腺疾病网络(OSU-PDN),B)提出了两项研究供联盟考虑,c)概述了我们的临床和转化研究基础设施。我们小组在CP和T3 cDM中的几个关键实验观察结果需要确认[OSU-PDN]和验证[CSCPDPC-CC]:1)CP受试者的胰腺液(PF)和尿(U)的蛋白质组学分析揭示了几种胰腺液蛋白-SERPINA 5、ANXA 5、CST 3的统计学显著倍数变化。(候选胰液标志物)和尿蛋白-CPN 2,A1 AG 1,AMYP(候选尿液标记物),以及2)观察到血清胰腺多肽对混合餐的反应存在显著差异,这可能将T3 cDM与更普遍的T2 DM区分开来。这些初步观察结果是我们研究建议的重点,供联合指导委员会考虑。我们的临床中心将由俄亥俄州州立大学临床和转化科学中心(CCTS/CTSA)与OSU-PDN和联盟中我们的“网络合作伙伴”的其他CTSA合作进行集中协调。CCTS/CTSA提供咨询服务,并提供临床和转化研究基础设施。这种独特的资源将帮助我们的团队与CDMC、DSMB和NIDDK中央存储库进行沟通。我们网络的两项研究提案都解决了NIDDK-国家消化疾病委员会概述的慢性胰腺炎,糖尿病和胰腺癌的知识和理解方面的差距,并与慢性胰腺炎,糖尿病和胰腺癌临床中心研究联盟(CSCPDPC-CC)的目标战略一致(U 01)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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专利数量(0)
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PAMELA G. BANKS其他文献
PAMELA G. BANKS的其他文献
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{{ truncateString('PAMELA G. BANKS', 18)}}的其他基金
NIMH-COR Honors High School Research Education Grant
NIMH-COR 授予高中研究教育补助金
- 批准号:
6317685 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH-COR Honors High School Research Education Grant
NIMH-COR 授予高中研究教育补助金
- 批准号:
6616798 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH COR HONORS HIGH SCHOOL RESEARCH EDUCATION GRANT
NIMH COR 授予高中研究教育补助金
- 批准号:
2890949 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH COR HONORS HIGH SCHOOL RESEARCH EDUCATION GRANT
NIMH COR 授予高中研究教育补助金
- 批准号:
2675638 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH COR HONORS HIGH SCHOOL RESEARCH EDUCATION GRANT
NIMH COR 授予高中研究教育补助金
- 批准号:
6186448 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH-COR Honors High School Research Education Grant
NIMH-COR 授予高中研究教育补助金
- 批准号:
6538788 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH-COR Honors High School Research Education Grant
NIMH-COR 授予高中研究教育补助金
- 批准号:
6900256 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH-COR Honors High School Research Education Grant
NIMH-COR 授予高中研究教育补助金
- 批准号:
6758629 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH COR HONORS HIGH SCHOOL RESEARCH EDUCATION GRANT
NIMH COR 授予高中研究教育补助金
- 批准号:
2035741 - 财政年份:1997
- 资助金额:
$ 49.4万 - 项目类别:
NIMH COR HONORS UNDERGRADUATE RESEARCH TRAINING
NIMH COR 荣誉本科生研究培训
- 批准号:
6185403 - 财政年份:1981
- 资助金额:
$ 49.4万 - 项目类别:
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