Topical Microparticle Delivery for Burn Pain Control

用于控制烧伤疼痛的局部微粒输送

• 批准号: 8900104
• 负责人: Joseph C. Salamone
• 金额: $ 22.39万
• 依托单位: ROCHAL INDUSTRIES, LLP
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8900104
• 关键词: Acute Pain; Adverse effects; Affinity; Analgesics; Bandage; Burn injury; Burning Pain; Caring; Characteristics; Child; Clinical; Dermis; Drug Delivery Systems; Drug Formulations; Effectiveness; Encapsulated; Evaluation; Exhibits; Family; Future; Government; Industry; Injection of therapeutic agent; Injury; Intravenous; Investigation; Ketoconazole; Lead; Liquid substance; Medical; Methodology; Modeling; Nature; Nerve; Nordihydroguaiaretic Acid; Opioid; Oral; Pain; Pain Origin; Pain management; Painless; Penetration; Peripheral Nervous System Diseases; Persons; Pharmaceutical Preparations; Phase; Polymers; Process; Property; Rehabilitation therapy; Research; Rodent; Rodent Model; Silicones; Site; Solutions; Solvents; Source; Surface; Surface Tension; System; Technology; Testing; Therapeutic; Therapeutic Agents; Thick; Tissues; Topical application; Treatment Efficacy; Treatment Protocols; base; chronic pain; commercial application; controlled release; design; improved; in vivo; injured; innovation; point of care; public health relevance; receptor; standard of care; technological innovation; wound

 DESCRIPTION (provided by applicant): There is a critical need for improved treatments for pain associated with burn injury. Pain control after burn injury is a major challenge from the initial point of care through rehabilitation. The overall objective of this project is to develop a easily-applied topical delivery system based on analgesic microparticles that can be used for treatment of pain associated with deep partial thickness burns. One of the critical barriers to progress is that current therapies are administered systemically with concomitant side effects in addition to often insufficient pain relief - no topical treatments are available to treat burn pain This new topical treatment approach is designed to target pain at the source, lowering usage of systemic opioids or other treatments, thus reducing unwanted side effects associated with the current systemic treatments and enhancing the effectiveness of burn pain relief. A key focus of this research is to determine which microparticle topical delivery system has the highest potential for burn pain relief. The application of peripherally-acting analgesics has been designed to provide effective, simple-to-use, easily and painlessly applied treatment of pain associated with burn injury. This topical microparticle delivery technology has the potential to lead to a marketable product and the proposed technology will improve current treatment methodologies for burn injury and pain. The first specific aim is to incorporate therapeutic agents into the topical delivery system. The second aim is to evaluate drug release characteristics ex vivo using a bioartificial dermis system. The third specific aim is to select th formulation for in vivo testing utilizing a team of clinical burn and scientific pain experts. The fourth specific aim is to evaluate the efficacy of the optimized delivery system in vivo using a rodent burn model. The resulting product is being designed to be a unique topical delivery system that can be used to painlessly apply analgesic treatment for burn pain. The impact of this research is to help the millions of victims, many of whom are children and wounded warriors, who have debilitating acute and chronic pain resulting from burns.

 描述（由申请人提供）：迫切需要改进烧伤相关疼痛的治疗方法。烧伤后的疼痛控制是从最初的护理到康复的一个主要挑战。本项目的总体目标是开发一种基于镇痛微粒的易于应用的局部给药系统，可用于治疗与深二度烧伤相关的疼痛。进展的关键障碍之一是，目前的治疗是全身施用的，除了通常不充分的疼痛缓解之外，还伴随有副作用-没有局部治疗可用于治疗烧伤疼痛。这种新的局部治疗方法被设计为在源头靶向疼痛，减少全身阿片类药物或其他治疗的使用，从而减少与当前全身治疗相关的不希望的副作用并增强减轻烧伤疼痛的有效性。这项研究的一个重点是确定哪种微粒局部给药系统具有最大的缓解烧伤疼痛的潜力。外周作用镇痛药的应用旨在为烧伤相关疼痛提供有效、易于使用、易于无痛的治疗。这种局部微粒递送技术有可能导致可销售的产品，并且所提出的技术将改善目前用于烧伤和疼痛的治疗方法。第一个具体目标是将治疗剂掺入局部递送系统中。第二个目的是使用生物人工真皮系统评价离体药物释放特性。第三个具体目标是利用临床烧伤和科学疼痛专家团队选择用于体内测试的制剂。第四个具体目的是使用啮齿动物烧伤模型评价优化的递送系统在体内的功效。由此产生的产品被设计成一种独特的局部给药系统，可用于无痛应用止痛治疗烧伤疼痛。这项研究的影响是帮助数百万受害者，其中许多是儿童和受伤的战士，他们因烧伤而遭受急性和慢性疼痛。