Training Program on HIV Diversity and Drug Resistance-Enhancing Research Capacity

艾滋病毒多样性和增强耐药性研究能力培训计划

• 批准号: 8807957
• 负责人: Phillipe N Nyambi
• 金额: $ 27.4万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8807957
• 关键词: Address; Antiretroviral drug resistance; Biometry; Cameroon; Computer Analysis; Country; Data; Detection; Diagnosis; Diagnostic; Drug resistance; Educational workshop; Epidemiology; Evolution; Genetic Variation; Goals; Grant; HIV; HIV-1; Immunologics; Infection; Laboratories; Medical; Mentors; Molecular Biology; Monitor; New York; Postdoctoral Fellow; Prevention; Prevention program; Property; Research; Research Training; Testing; Training; Training Programs; Variant; Viral; Work; Writing; design; genetic evolution; improved; intervention program; new technology; pre-doctoral; programs; quality assurance; resistance mutation; resistant strain; skills; virus genetics

DESCRIPTION (provided by applicant): The broad HIV-1 genetic diversity and the emergence of drug resistant variants in Cameroon adds to complicate the viral genetic diversity and poses potential problems for diagnosis and prevention efforts, requiring that the evolution of HIV-1 diversity be monitored, and that new HIV-1 variants be examined for sensitivity of detection by different HIV-1 test kits. These problems continue to underscore the need for further training and research in Cameroon. This training program entitled "Training Program on HIV Diversity and Drug Resistance: enhancing research capacity" is designed with long-term to build and strengthen research capacity at the Medical Diagnostic Center in Yaounde, Cameroon for conducting studies to 1) document and monitor HIV-1 genetic diversity and evolution; 2) document and monitor the emergence antiretroviral drug resistant HIV-1 variants; 3) study the biologic and immunologic properties of different HIV-1 variants including emerging and drug resistant strains; 4) monitor the ability of commercially available test kits to diagnose infection by caused by diverse HIV-1 strains; and 5) to improve quality assurance and laboratory biosafety. To achieve these objectives we will: a) Organize in-country training workshops that will provide short-term local onsite training on: i) quality assurance and laboratory biosafety; ii new technologies and commercially available test kits for the diagnosis of infections caused by diverse HIV strains; and iii) scientific and grant writing skills. b) Provide long-term training in New York for studies of molecular biology/epidemiology/biostatistics relevant to studies of HIV genetic diversity through non-degree or degree programs for pre- and post-doctoral fellows. c) Provide medium-term training in New York for fellows to perform hands-on-laboratory training on viral genetic subtype characterization and computational analysis to document and identify diverse HIV-1 strains and/or drug resistance mutations, and viral biologic and immunologic properties. d) Provide short-term training through hands-on-training in documenting drug resistance mutations and data interpretation, to attend courses on epidemiology and biostatistics and to work one-on-one with relevant mentors. And, e) To support in-country research by providing small grants to appropriate long-term "alumni" fellows to conduct studies that addresses the research goals of the MDC. This training program should build and strengthen the research capacity at MDC to conduct studies on HIV-1 diversity and drug resistance that are relevant to intervention and prevention programs in Cameroon.

描述（由申请人提供）：喀麦隆广泛的 HIV-1 遗传多样性和耐药变体的出现使病毒遗传多样性变得更加复杂，并给诊断和预防工作带来潜在问题，需要监测 HIV-1 多样性的演变，并检查新的 HIV-1 变体的不同 HIV-1 检测试剂盒检测的敏感性。这些问题继续强调喀麦隆需要进一步的培训和研究。该培训计划题为“艾滋病毒多样性和耐药性培训计划：增强研究能力”，旨在长期建设和加强喀麦隆雅温得医学诊断中心的研究能力，以开展以下研究：1) 记录和监测 HIV-1 遗传多样性和进化； 2) 记录并监测抗逆转录病毒药物耐药性 HIV-1 变异体的出现； 3) 研究不同HIV-1变体的生物学和免疫学特性，包括新出现的和耐药的毒株； 4) 监测市售检测试剂盒诊断不同 HIV-1 毒株引起的感染的能力； 5) 提高质量保证和实验室生物安全。为了实现这些目标，我们将： a) 组织国内培训研讨会，提供以下方面的短期本地现场培训： i) 质量保证和实验室生物安全； ii 用于诊断不同艾滋病毒株引起的感染的新技术和市售检测试剂盒； iii) 科学和拨款写作技巧。 b) 提供长期培训 纽约，通过为博士前和博士后研究员提供非学位或学位课程，研究与艾滋病毒遗传多样性研究相关的分子生物学/流行病学/生物统计学。 c) 在纽约为研究员提供中期培训，以进行有关病毒遗传亚型表征和计算分析的实验室实践培训，以记录和识别不同的 HIV-1 毒株和/或耐药突变以及病毒生物学和免疫学特性。 d) 通过记录耐药突变和数据解释的实践培训提供短期培训，参加流行病学和生物统计学课程，并与相关导师进行一对一的工作。并且，e) 通过向适当的长期“校友”研究员提供小额赠款来支持国内研究，以开展旨在实现 MDC 研究目标的研究。该培训计划应建立和加强 MDC 的研究能力，以开展与喀麦隆干预和预防计划相关的 HIV-1 多样性和耐药性研究。