Prolonged Overnight Fasting for Reducing Breast Cancer Risk

延长隔夜禁食可降低乳腺癌风险

基本信息

批准号：
8912268
负责人：
Catherine Marinac
金额：
$ 2.97万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2016-06-10
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8912268
关键词：
Address Adult Advisory Committees Advocate American Animals Area Bachelor&apos s Degree Behavioral Biochemistry Biological Biological Markers Blood Glucose Body Weight decreased Body mass index Breast Breast Cancer Prevention Breast Cancer survivor C-reactive protein California Cancer Center Cancer Prognosis Circadian Rhythms Clinic Clinical Communication Complement Data Data Analyses Data Sources Development Diabetes Mellitus Diagnosis Diet Dietary Practices Digestive System Disorders Eating Educational Background Effectiveness Environment Epidemic Fasting Fatty Liver Fellowship Funding Gene Proteins General Population Goals Health behavior Hemoglobin Hour Human Hyperinsulinism Incidence Individual Inflammation Institutes Insulin Insulin Resistance Intake Intervention Joints Kidney Diseases Knowledge Life Life Style Light Link Malignant Neoplasms Mentorship Metabolic Metabolic Pathway Metabolism Modeling Molecular Biology Mus National Health and Nutrition Examination Survey Obesity Observational Study Population Population Study Postmenopause Predoctoral Individual National Research Service Award Prevention program Prevention strategy Publishing Randomized Controlled Trials Recording of previous events Recurrence Regimen Reporting Research Research Activity Research Personnel Research Project Grants Research Training Risk Risk Factors Sampling Schedule Series Serum Societies Staging Students Surveys Survivors Time Training Training Activity United States United States National Institutes of Health Universities Woman Writing cancer prevention cancer risk carcinogenesis career career development cohort diabetes risk doctoral student energy balance experience feeding healthy volunteer high risk innovation insulin sensitivity lifestyle factors lifestyle intervention malignant breast neoplasm meetings men mortality novel nutrition obesity prevention outcome forecast pre-doctoral programs public health intervention public health relevance public health research skills statistics stem survivorship undergraduate research

项目摘要

DESCRIPTION (provided by applicant): This F31 proposal features a wide-ranging program of training activities, mentorship, and research projects that will provide me with the support, knowledge, and skills needed to progress towards my career goal of becoming an independent investigator in area of obesity, metabolism, and cancer prevention/survivorship. My educational background, training history, and research activities demonstrate a continued commitment and progression towards achieving these career goals. I received my undergraduate degree in Biochemistry from Lawrence University, completed a series of undergraduate research fellowships in molecular biology at Rochester's Mayo Clinic, and completed a pre-doctoral fellowship in energy balance and human nutrition/metabolism with the National Institute of Diabetes and Digestive and Kidney Diseases (NIH Clinical Center). I am currently a doctoral student in the San Diego State University/University of California,San Diego (UCSD) joint Doctoral Program in Health Behavior (Public Health), and research student at the Moores UCSD Cancer Center. The overall objective of the proposed F31 training fellowship is to enable me to build from my previous training experiences in biochemistry, human metabolism, and breast cancer prevention, by exploring how dietary patterns influence metabolic pathways of breast cancer risk. The proposed training plan will allow me to gain advanced knowledge and skills in the following areas: (1) biologic mechanisms that link obesity, diabetes, and lifestyle t carcinogenesis, (2) advanced statistics for analysis of biological variables and survey data, (3) scientific writing and communication, and (4) networking and career development. UCSD is the ideal environment for me to pursue these goals, due to its exceptionally strong group of lifestyle and cancer researchers, and the presence of an NCI-funded Transdisciplinary Research on Energetics and Cancer (TREC) Center. Notably, investigators from the Moores UCSD Cancer Center led the Women's Healthy Eating and Living (WHEL) study, which is providing data for the proposed analyses involving breast cancer survivors. The support provided by an F31 award will provide me with the protected time to expand my research focus and develop advanced skills in data analysis and scientific writing. The training activities and research projects described in this proposal will complement my previous research and training experiences and enable me to deepen my knowledge and understanding of the relationships between lifestyle factors (i.e., fasting duration) and metabolic pathways of cancer development.

描述（由申请人提供）：该F31提案具有广泛的培训活动，指导和研究项目的计划，这些计划将为我提供朝着我的职业生涯目标的支持，知识和技能，即成为我成为肥胖，代谢和预防癌症预防/生存的独立研究人员的职业目标。我的教育背景，培训历史和研究活动表明，致力于实现这些职业目标的持续承诺和发展。我在劳伦斯大学获得了生物化学的本科学位，在罗切斯特的梅奥诊所完成了一系列分子生物学研究奖学金，并与国家糖尿病和消化道和卵子诊所（NIH Clines）（NIH IHIH中心）完成了能源平衡和人类营养/代谢的能源平衡和人类营养/代谢的博士前研究。我目前是圣地亚哥州立大学/加利福尼亚大学圣地亚哥大学（UCSD）健康行为联合博士学位（公共卫生）的博士生，以及摩尔UCSD UCSD癌症中心的研究生。拟议的F31培训奖学金的总体目标是使我能够通过探索饮食模式如何影响乳腺癌风险的新陈代谢途径，从以前的生物化学，人类代谢和预防乳腺癌的培训经验来建立。拟议的培训计划将使我能够在以下领域获得高级知识和技能：（1）将肥胖，糖尿病和生活方式的生物学机制联系起来，（2）用于分析生物学变量和调查数据的先进统计数据，（3）科学写作和交流，以及（4）网络和职业发展。由于其极强的生活方式和癌症研究人员以及NCI资助的有关能量和癌症中心（TREC）中心的跨学科研究，UCSD是我追求这些目标的理想环境。值得注意的是，摩尔UCSD癌症中心的研究人员领导了妇女的健康饮食和生活（WHEL）研究，该研究正在为涉及乳腺癌幸存者的拟议分析提供数据。 F31奖提供的支持将为我提供受保护的时间，以扩大我的研究重点并发展数据分析和科学写作方面的先进技能。该提案中描述的培训活动和研究项目将补充我以前的研究和培训经验，使我能够加深对生活方式因素（即禁食持续时间）和癌症发展的代谢途径之间关系的了解和理解。