A wearable asthma trigger monitoring system with integrated physiological monitor

具有集成生理监测器的可穿戴式哮喘触发监测系统

• 批准号: 9076017
• 负责人: Alicia Esperanza Meuret
• 金额: $ 196.37万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9076017
• 关键词: Address; Adolescent; Advisory Committees; Affect; Air; Air Pollution; Algorithms; Allergens; Asthma; Awareness; Behavioral; Breathing; Carbon Dioxide; Centers for Disease Control and Prevention (U.S.); Child; Childhood Asthma; Chronic; Chronic Disease; Classification; Consumption; Data; Development; Devices; Disease; Economically Deprived Population; Elements; Emotional Stress; Engineering; Environmental Monitoring; Environmental Risk Factor; Exhalation; Exposure to; Extrinsic asthma; Family; Goals; Guidelines; Health; Heart Rate; Hypersensitivity; Hypocapnia; Individual; Individual Differences; Inflammatory; Inhalators; Laboratories; Life; Light; Measurement; Measures; Minority; Molds; Monitor; Movement; National Institute of Biomedical Imaging and Bioengineering; Neighborhoods; Particulate; Particulate Matter; Patients; Personal Satisfaction; Pharmaceutical Preparations; Pharmacological Treatment; Physical activity; Physicians; Physiologic Monitoring; Physiological; Pilot Projects; Pollen; Population; Predisposition; Prevalence; Protocols documentation; Psychologist; Pulmonology; Radar; Recruitment Activity; Research; Sampling; Scientist; Self Management; Side; Site; Smoke; Staging; Stream; Symptoms; System; Systems Integration; Testing; Time; United States; Validation; Weight; Work; adolescent patient; asthmatic patient; base; design; experience; light scattering; multidisciplinary; novel; patient advocacy group; pediatric patients; programs; public health relevance; pyroglyphid; response; sensor; success

 DESCRIPTION (provided by applicant): Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which extoll a substantial burden on the patients' well-being and can be life threatening if not controlled adequately. Despite progress in the pharmacological treatment of asthma, overall asthma control remains unsatisfactory. Although trigger avoidance is recognized as a key element of asthma self-management, and elaborate trigger avoidance modules have been developed and distributed, their actual implementation has had mixed success. Problems lie in the variety of potential triggers, lack of systematic monitoring of triggers, and unobtrusive physiological monitors for conditions like hypocapnia are still missing. The goal of this proposal is to develop a comprehensive monitoring system that will allow simultaneous monitoring of critical environmental triggers of asthma symptoms and/or exacerbations as well as real-time physiological status of pediatric asthma patients. This will provide patients with objective information about their momentary trigger exposure with the potential to guide personalized trigger avoidance strategies and will better inform research about the factors that underlie asthma symptoms/exacerbation in daily life. We have assembled a unique and closely knit multidisciplinary team of engineers, physicians, and health psychologists. We will also be guided by and work closely with a strong External Advisory Committee and program staff at the NIBIB at all stages of the project.

 描述（由申请方提供）：哮喘是一种慢性炎症性气道疾病，可导致发作性症状加重，对患者的健康造成重大负担，如果控制不当，可能危及生命。尽管哮喘的药物治疗取得了进展，但总体哮喘控制仍不令人满意。虽然触发避免被认为是哮喘自我管理的一个关键因素，精心设计的触发避免模块已经开发和分发，他们的实际实施有喜忧参半。问题在于潜在的触发因素的多样性，缺乏对触发因素的系统监测，以及对低碳酸血症等状况的不显眼的生理监测器仍然缺失。本提案的目标是开发一个全面的监测系统，该系统将允许同时监测哮喘症状和/或急性发作的关键环境触发因素以及儿科哮喘患者的实时生理状态。这将为患者提供有关其瞬时触发暴露的客观信息，有可能指导个性化的触发避免策略，并将更好地为有关日常生活中哮喘症状/急性发作的因素的研究提供信息。我们组建了一支由工程师、医生和健康心理学家组成的独特而紧密的多学科团队。在项目的各个阶段，我们还将接受强大的外部咨询委员会和NIBIB项目人员的指导，并与他们密切合作。