Osteoporosis treatment response assessed by micromechanical modeling of MRI data.

通过 MRI 数据的微机械模型评估骨质疏松症治疗反应。

基本信息

  • 批准号:
    8899442
  • 负责人:
  • 金额:
    $ 50.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-07 至 2016-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Osteoporosis and low bone mass are currently estimated to be a major public health threat for almost 44 million U.S. women and men aged 50 and older. While the disorder affects both genders, approximately 80% of those having the condition are women. After menopause and the concomitant decline in estrogen levels, bone undergoes structural changes and reduction in tissue volume density resulting in reduced strength and increased fracture susceptibility. Even though effective treatment is available, the high cost and numerous side effects of antiresorptive and anabolic drugs have spurred the search for alternative therapies. Equally important, however, is that pharmacologic intervention is generally not indicated until subjects have progressed to a level of bone density commensurate with the diagnosis of osteoporosis. It has recently been shown that low-magnitude mechanical stimulation (LMMS) at frequencies of tens of Hertz is osteogenic, presumably via downregulation of the nuclear hormone receptor, PPAR, resulting in preferential differentiation of marrow stromal cells toward the osteoblastic instead of the adipocytic lineage. This competing renewal project seeks to further develop methods for image-based micro-finite-element modeling for quantifying various properties of skeletal mechanical competence, along with improved methods for high-resolution structural magnetic resonance (MR) imaging of cortical and trabecular bone, and measurement of bone marrow composition by MR spectroscopic imaging. The resulting protocol will be applied in a subsequent randomized, double-blinded, translational patient study to evaluate the hypothesis that early postmenopausal women, subjected to a daily 10-minute treatment of LMMS for one year, will show an improvement in trabecular and cortical stiffness and failure strength at the tibia, along with a reduction in vertebral marrow adiposity relative to their placebo-treated peers. The successful completion of the project will provide new insight into the potential for image-based computational biomechanics for monitoring prophylactic intervention.
描述(由申请人提供):骨质疏松症和低骨量目前估计是近4400万美国50岁及以上女性和男性的主要公共卫生威胁。虽然这种疾病对两性都有影响,但大约80%的患者是女性。绝经后,伴随着雌激素水平的下降,骨骼发生结构变化,组织体积密度降低,导致强度降低,骨折易感性增加。尽管有有效的治疗方法,但抗吸收和合成代谢药物的高成本和众多副作用促使人们寻找替代疗法。然而,同样重要的是,在受试者的骨密度达到与骨质疏松症诊断相适应的水平之前,通常不建议进行药物干预。最近有研究表明,几十赫兹频率的低强度机械刺激(LMMS)可能是通过下调核激素受体PPAR,导致骨髓基质细胞向成骨细胞而不是脂肪细胞谱系的优先分化,从而成骨。这个竞争性的更新项目旨在进一步开发基于图像的微有限元建模方法,用于量化骨骼机械能力的各种特性,以及改进的皮质骨和小梁骨的高分辨率结构磁共振(MR)成像方法,以及通过MR光谱成像测量骨髓成分。由此产生的方案将应用于随后的一项随机、双盲、转化患者研究,以评估这样一种假设:早期绝经后妇女,每天接受10分钟的LMMS治疗一年,将显示出胫骨小梁和皮质刚度和失效强度的改善,以及相对于安慰剂治疗的同龄人椎髓脂肪的减少。该项目的成功完成将为基于图像的计算生物力学监测预防性干预的潜力提供新的见解。

项目成果

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Felix W Wehrli其他文献

Structural and functional evaluation of the peripheral vasculature in patients with PAD using MRI
  • DOI:
    10.1186/1532-429x-17-s1-p406
  • 发表时间:
    2015-02-03
  • 期刊:
  • 影响因子:
  • 作者:
    Erin K Englund;Michael C Langham;Emile R Mohler;Thomas F Floyd;Felix W Wehrli
  • 通讯作者:
    Felix W Wehrli
Acute exposure to e-cigarettes causes inflammation and endothelial oxidative stress in non-smoking healthy young subjects.
急性接触电子烟会导致不吸烟的健康年轻受试者出现炎症和内皮氧化应激。

Felix W Wehrli的其他文献

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{{ truncateString('Felix W Wehrli', 18)}}的其他基金

MRI-Based Renal Oximetry in Early Diabetic Kidney Disease
基于 MRI 的肾血氧饱和度在早期糖尿病肾病中的应用
  • 批准号:
    10593684
  • 财政年份:
    2023
  • 资助金额:
    $ 50.47万
  • 项目类别:
MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLD
通过 3D 定量 BOLD 进行基于 MRI 的脑代谢区域评估
  • 批准号:
    10578782
  • 财政年份:
    2022
  • 资助金额:
    $ 50.47万
  • 项目类别:
MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLD
通过 3D 定量 BOLD 进行基于 MRI 的脑代谢区域评估
  • 批准号:
    10373235
  • 财政年份:
    2022
  • 资助金额:
    $ 50.47万
  • 项目类别:
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
人类耗氧量的高时空分辨率 MRI 绘图
  • 批准号:
    10490825
  • 财政年份:
    2021
  • 资助金额:
    $ 50.47万
  • 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
  • 批准号:
    10490338
  • 财政年份:
    2021
  • 资助金额:
    $ 50.47万
  • 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
  • 批准号:
    10353104
  • 财政年份:
    2021
  • 资助金额:
    $ 50.47万
  • 项目类别:
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
人类耗氧量的高时空分辨率 MRI 绘图
  • 批准号:
    10172052
  • 财政年份:
    2021
  • 资助金额:
    $ 50.47万
  • 项目类别:
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
人体耗氧量的高时空分辨率 MRI 绘图
  • 批准号:
    10669230
  • 财政年份:
    2021
  • 资助金额:
    $ 50.47万
  • 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
  • 批准号:
    10688286
  • 财政年份:
    2021
  • 资助金额:
    $ 50.47万
  • 项目类别:
Noninvasive Quantification of Age-Related Alterations in Sleep-Dependent CMRO2 Attenuation Using EEG-Correlated MRI
使用脑电图相关 MRI 对睡眠依赖性 CMRO2 衰减中与年龄相关的变化进行无创量化
  • 批准号:
    10227190
  • 财政年份:
    2020
  • 资助金额:
    $ 50.47万
  • 项目类别:

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