High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
人类耗氧量的高时空分辨率 MRI 绘图
基本信息
- 批准号:10490825
- 负责人:
- 金额:$ 16.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-20 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAffectBloodBlood VesselsBlood flowBrainBreathingCalibrationCarrying CapacitiesCategoriesCellsCerebrumClinicClinicalClinical MedicineConsumptionCouplingDataDegenerative DisorderDevelopmentDiseaseDoctor of PhilosophyEquationErythrocytesEvaluationFetusFunctional Magnetic Resonance ImagingGasesHeme IronHemoglobinHumanHypercapniaHyperoxiaImaging technologyInformation DisseminationInstitutionInterventionKnowledgeLaboratoriesLife StyleMagnetic Resonance ImagingMagnetismMapsMeasurementMeasuresMediatingMetabolicMetabolic DiseasesMetabolismMethodsModelingMole the mammalOpticsOrganOxygenOxygen ConsumptionOxygen saturation measurementPatientsPerformancePhysiologicalPlacentaPredispositionPreparationProtocols documentationPublishingQuantitative EvaluationsRelaxationReproducibilityResearch PersonnelResponse to stimulus physiologySignal TransductionStandardizationTechniquesTechnologyTestingTimeTissuesTranslatingTranslationsValidationWaterWorkbaseblood oxygen level dependentbody systemdiagnosis evaluationextracellularfallsimaging modalityin uteroin vivointerestmagnetic fieldmetabolic imagingmetabolic ratemilliliterneural stimulationnew technologyprecision medicineresponsesignal processingtechnology developmenttemporal measurementtreatment responsewater diffusion
项目摘要
TR&D2: High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
Project PI: Felix Wehrli, Ph.D.
Abstract
Disturbance of oxygen metabolism is at the core of many degenerative and acquired disorders.
Therefore, knowledge of the metabolic rate of oxygen (MRO2), i.e. the rate of an organ’s O2 consumption,
expressed in moles or milliliter of O2 metabolized per minute and unit mass of tissue, is fundamental to
understanding tissue metabolism and one of the key physiologic parameters of interest to clinical medicine.
Substrate and oxygen delivery to the cells are both mediated by blood flow. Thus, quantification of MRO2
demands knowledge of both, the change in fractional blood oxygen content following substrate metabolization -
- usually expressed in terms of oxygen extraction fraction (OEF) -- and blood flow rate.
MRI is the only imaging modality permitting truly noninvasive evaluation of MRO2. While blood flow can
be measured accurately and reproducibly to render it clinically practical, the measurement of OEF proves to be
a far more intricate problem. Two dominant approaches exploiting heme iron magnetism in hemoglobin’s deoxy
state have emerged; direct measurement of blood magnetic susceptibility via some form of quantitative
susceptibility mapping, or indirectly via measurement of blood water transverse relaxation resulting from rapid
exchange between intra- and extracellular erythrocyte compartments as well as water diffusion in the locally
induced magnetic fields.
A number of embodiments of susceptometry-based oximetry, as well as T2-based whole-organ and
regional BOLD-based oximetry, conceived by the investigators in preliminary work, or published by others, have
shown promise. However, precision medicine demands robustness, accuracy and reproducibility of the derived
quantitative measures in order to be applicable to diagnosis and evaluation of treatment response. None of these
requirements are currently meet the necessary standard of rigor. Further, since the effects measured with any
of the above methods scale with field strength, a rigorous quantitative evaluation will be needed. To attain these
objectives, the present TR&D proposes to develop and validate; MRI-based imaging technologies for whole-
organ MRO2 measurement at high temporal resolution applicable to multiple organ systems (Aim 1), spatially
resolved MRO2 based on the principles of both calibrated and quantitative BOLD focusing on the human brain
(Aim 2); and full cross-validation and expansion to 7T field strength (Aim 3).
The results of the proposed technology developments and dissemination of the ensuing methods within
the applicants’ institution and beyond, should provide effective means for the study of tissue energetics in
vascular-metabolic disorders in response to treatment and lifestyle changes. Implementation, testing and
validation of the new technologies, and their eventual translation to the clinic, will open new avenues for
evaluating oxygen metabolism in multiple organs, thereby providing robust quantitative metrics for evaluation of
patients with metabolic and degenerative disorders.
TR&D2:人类耗氧量的高时空分辨率MRI映射
项目PI:Felix Wehrli,Ph.D.
摘要
氧代谢紊乱是许多退行性和获得性疾病的核心。
因此,了解氧代谢率(MRO 2),即器官的O2消耗率,
以每分钟代谢的O2的摩尔或毫升和组织的单位质量表示,
了解组织代谢和临床医学感兴趣的关键生理参数之一。
基质和氧气输送到细胞都是由血流介导的。因此,MRO 2的定量
需要了解这两方面的知识,即底物代谢后血氧含量的变化-
- 通常用氧摄取分数(OEF)和血液流速来表示。
MRI是唯一允许真正无创评估MRO 2的成像方式。虽然血流可以
准确和可重复地测量,使其临床实用,OEF的测量被证明是
一个更复杂的问题血红蛋白脱氧中血红素铁磁性的两种主要开发途径
通过某种形式的定量测量直接测量血液磁化率
敏感性映射,或间接通过测量血液水横向弛豫造成的快速
红细胞内和细胞外室之间的交换以及局部
感应磁场
基于血氧饱和度测定法的血氧测定法以及基于T2的全器官和
由研究者在前期工作中设想或由其他人发表的基于BOLD的区域血氧测定法,
显示承诺。然而,精准医学要求衍生产品的鲁棒性,准确性和重现性
定量测量,以便适用于治疗反应的诊断和评价。没有这些
目前的要求符合必要的严格标准。此外,由于任何测量的效果
上述方法与场强的比例,将需要严格的定量评估。实现这些
目标,目前的TR&D建议开发和验证;基于MRI的成像技术,
适用于多器官系统的高时间分辨率器官MRO 2测量(目标1),空间
基于校准和定量BOLD聚焦于人脑的原理,
(Aim 2);和全面的交叉验证和扩展到7 T场强(目标3)。
拟议技术开发的结果和随后方法的传播,
申请人的机构和其他机构应提供有效的组织能量学研究手段,
血管代谢紊乱对治疗和生活方式改变的反应。实施、测试和
新技术的验证,以及它们最终转化为临床,将为以下方面开辟新的途径:
评估多个器官中的氧代谢,从而为评估
代谢和退行性疾病患者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Felix W Wehrli其他文献
Structural and functional evaluation of the peripheral vasculature in patients with PAD using MRI
- DOI:
10.1186/1532-429x-17-s1-p406 - 发表时间:
2015-02-03 - 期刊:
- 影响因子:
- 作者:
Erin K Englund;Michael C Langham;Emile R Mohler;Thomas F Floyd;Felix W Wehrli - 通讯作者:
Felix W Wehrli
Acute exposure to e-cigarettes causes inflammation and endothelial oxidative stress in non-smoking healthy young subjects.
急性接触电子烟会导致不吸烟的健康年轻受试者出现炎症和内皮氧化应激。
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
S. Chatterjee;Jian;Alyssa J Johncola;Wensheng Guo;A. Caporale;M. Langham;Felix W Wehrli - 通讯作者:
Felix W Wehrli
Felix W Wehrli的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Felix W Wehrli', 18)}}的其他基金
MRI-Based Renal Oximetry in Early Diabetic Kidney Disease
基于 MRI 的肾血氧饱和度在早期糖尿病肾病中的应用
- 批准号:
10593684 - 财政年份:2023
- 资助金额:
$ 16.79万 - 项目类别:
MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLD
通过 3D 定量 BOLD 进行基于 MRI 的脑代谢区域评估
- 批准号:
10578782 - 财政年份:2022
- 资助金额:
$ 16.79万 - 项目类别:
MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLD
通过 3D 定量 BOLD 进行基于 MRI 的脑代谢区域评估
- 批准号:
10373235 - 财政年份:2022
- 资助金额:
$ 16.79万 - 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10490338 - 财政年份:2021
- 资助金额:
$ 16.79万 - 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10353104 - 财政年份:2021
- 资助金额:
$ 16.79万 - 项目类别:
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
人类耗氧量的高时空分辨率 MRI 绘图
- 批准号:
10172052 - 财政年份:2021
- 资助金额:
$ 16.79万 - 项目类别:
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans
人体耗氧量的高时空分辨率 MRI 绘图
- 批准号:
10669230 - 财政年份:2021
- 资助金额:
$ 16.79万 - 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10688286 - 财政年份:2021
- 资助金额:
$ 16.79万 - 项目类别:
Noninvasive Quantification of Age-Related Alterations in Sleep-Dependent CMRO2 Attenuation Using EEG-Correlated MRI
使用脑电图相关 MRI 对睡眠依赖性 CMRO2 衰减中与年龄相关的变化进行无创量化
- 批准号:
10227190 - 财政年份:2020
- 资助金额:
$ 16.79万 - 项目类别:
Noninvasive Quantification of Age-Related Alterations in Sleep-Dependent CMRO2 Attenuation Using EEG-Correlated MRI
使用脑电图相关 MRI 对睡眠依赖性 CMRO2 衰减中与年龄相关的变化进行无创定量
- 批准号:
10054870 - 财政年份:2020
- 资助金额:
$ 16.79万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 16.79万 - 项目类别:
Research Grant