Establishment and metabolic control of influenza-specific lung-resident memory B cells

流感特异性肺驻留记忆 B 细胞的建立和代谢控制

• 批准号: 8982505
• 负责人: S Rameeza Allie
• 金额: $ 5.34万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8982505
• 关键词: Affinity; Antibodies; Antibody Formation; Antibody Response; Antigens; Area; B cell repertoire; B-Lymphocytes; Binding; CD8B1 gene; Cell physiology; Cells; Data; Dichloroacetate; Disease model; Emigrant; Exhibits; Future; Genes; Glycolysis; Glycolysis Inhibition; IgG1; Image; Immune; Immunization; Immunoglobulin Class Switching; Immunoglobulin D; Immunoglobulin M; Immunoglobulin Somatic Hypermutation; Immunoglobulin-Secreting Cells; Immunotherapy; Infection; Influenza; Infusion procedures; Invaded; Life; Lung; Lymphoid; Mediating; Memory; Memory B-Lymphocyte; Metabolic; Metabolic Control; Metabolic Pathway; Metabolism; Modeling; Mus; Mutation; Outcome Study; PDH kinase; PTPRC gene; Pathway interactions; Pattern; Plasma Cells; Population; Proliferating; Readiness; Reporter; Repression; Resolution; Seeds; Signal Pathway; Signal Transduction; Site; Structure of germinal center of lymph node; T-Lymphocyte; Techniques; Testing; Transcriptional Regulation; Vaccines; Virus; Virus Diseases; Warburg Effect; cancer cell; glucose uptake; imprint; improved; influenza virus vaccine; influenzavirus; kinase inhibitor; lymph nodes; meetings; metabolomics; neutralizing antibody; novel; pathogen; preference; public health relevance; research study; response; vaccine trial

 DESCRIPTION (provided by applicant): This project will confirm the early establishment of a protective lung resident memory B cell (BRM) population, and investigate the metabolic pathways that poise these cells to form antibody-secreting cells (ASCs). Various groups have studied the formation of Ag specific memory B cells, but it has not been in the context of a pathogen that holds significant.

 描述（由申请人提供）：本项目将证实保护性肺驻留记忆B细胞（BRM）群体的早期建立，并研究平衡这些细胞形成抗体分泌细胞（ASC）的代谢途径。不同的研究小组已经研究了抗原特异性记忆B细胞的形成，但它还没有在病原体的背景下，具有重要意义。