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Establishment and metabolic control of influenza-specific lung-resident memory B cells

Establishment and metabolic control of influenza-specific lung-resident memory B cells
流感特异性肺驻留记忆 B 细胞的建立和代谢控制
批准号：
8982505
负责人：
S Rameeza Allie
金额：
$5.34万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-07-01 至 2018-06-30
来源：
https://reporter.nih.gov/project-details/8982505
关键词：
AffinityAntibodiesAntibody FormationAntibody ResponseAntigensAreaB cell repertoireB-LymphocytesBindingCD8B1 geneCell physiologyCellsDataDichloroacetateDisease modelEmigrantExhibitsFutureGenesGlycolysisGlycolysis InhibitionIgG1ImageImmuneImmunizationImmunoglobulin Class SwitchingImmunoglobulin DImmunoglobulin MImmunoglobulin Somatic HypermutationImmunoglobulin-Secreting CellsImmunotherapyInfectionInfluenzaInfusion proceduresInvadedLifeLungLymphoidMediatingMemoryMemory B-LymphocyteMetabolicMetabolic ControlMetabolic PathwayMetabolismModelingMusMutationOutcome StudyPDH kinasePTPRC genePathway interactionsPatternPlasma CellsPopulationProliferatingReadinessReporterRepressionResolutionSeedsSignal PathwaySignal TransductionSiteStructure of germinal center of lymph nodeT-LymphocyteTechniquesTestingTranscriptional RegulationVaccinesVirusVirus DiseasesWarburg Effectcancer cellglucose uptakeimprintimprovedinfluenza virus vaccineinfluenzaviruskinase inhibitorlymph nodesmeetingsmetabolomicsneutralizing antibodynovelpathogenpreferencepublic health relevanceresearch studyresponsevaccine trial

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英文摘要
 DESCRIPTION (provided by applicant): This project will confirm the early establishment of a protective lung resident memory B cell (BRM) population, and investigate the metabolic pathways that poise these cells to form antibody-secreting cells (ASCs). Various groups have studied the formation of Ag specific memory B cells, but it has not been in the context of a pathogen that holds significant.
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Determining the role of NLRP3 on the placement and protective potential of CD73+ BRMs post influenza infection
Establishment and metabolic control of influenza-specific lung-resident memory B cells
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