2014 Meiosis Gordon Research Conference & Gordon Research Seminar

描述（由申请人提供）：作为戈登研究会议（GRC）的一部分，减数分裂国际会议将于2014年6月1日至6日在新罕布什尔州新伦敦的科尔比-索耶学院举行。此外，减数分裂戈登研究研讨会（GRS）将在同一地点举行，在GRC之前（2014年5月31日至6月1日）。GRS是一个为期1.5天的会议，由研究生和博士后研究员组织，为初级研究人员提供了一个交流和讨论将在41/2天减数分裂GRC期间更深入讨论的主题的机会。会议的长期目标是了解在正常和疾病条件下确保减数分裂细胞分裂期间基因组稳定遗传的基本机制。会议的具体目标是：促进创新，在年轻和成熟的研究人员之间建立网络，迅速传播新的和未发表的结果，并促进跨学科的协同作用。GRC将聚集约175名参与者，包括53名演讲者，介绍和讨论前沿的，大部分未发表的研究。该计划包括9个全体会议，广泛讨论减数分裂重组，减数分裂进程和细胞周期检查点，减数分裂过程的表观遗传控制，减数分裂基因表达的调节，染色体配对和突触，姐妹染色单体内聚，染色体与核膜的相互作用，染色体分离，以及减数分裂过程的进化和自然变异。在整个会议期间，向所有与会者开放的四个海报会议将为扩展和深入的批判性讨论提供基础。海报会议是促进跨学科合作和新研究者加入网络的特别有价值的论坛。GRS将包括50至60名与会者，并将举行三次全体会议和一次海报会议。这一应用直接关系到人类健康。大约58%的人类受孕在减数分裂中出现错误，导致流产或与染色体异常有关的出生缺陷。此外，在减数分裂过程中修复程序性双链断裂的许多机制也有助于保护有丝分裂细胞免受有害DNA损伤。因此，了解减数分裂为基因组稳定性和预防癌症提供了新的见解。这两个会议汇集了研究生、博士后、年轻研究人员和成熟的pi，以推动生殖健康这一关键领域的创新和知识的前沿。

DESCRIPTION (provided by applicant): Partial support is requested for an international meeting on Meiosis as part of the Gordon Research Conferences (GRC) to be held at Colby-Sawyer College in New London, NH on June 1-6, 2014. In addition, support is requested for the Meiosis Gordon Research Seminar (GRS) that will be held in the same location, immediately prior to the GRC (May 31 - June 1, 2014). The GRS is a 1.5 day meeting, organized by graduate students and postdoctoral fellows, which offers an opportunity for junior researchers to network and discuss the topics that will be covered in more depth during the 41/2-day Meiosis GRC. The long term goal of the conferences is to understand the fundamental mechanisms that ensure the stabile inheritance of the genome during meiotic cell divisions in both normal and disease conditions. The specific aims of the meeting are to: foster innovation, create networks between young and established investigators, rapidly disseminate new and unpublished results, and promote interdisciplinary synergies. The GRC will gather approximately 175 participants, including 53 speakers, to present and discuss cutting-edge, mostly unpublished research. The program comprises 9 plenary sessions that broadly address current issues in meiotic recombination, meiotic progression and cell cycle checkpoints, epigenetic control of meiotic processes, regulation of meiotic gene expression, chromosome pairing and synapsis, sister chromatid cohesion, chromosome interactions with the nuclear envelope, chromosome segregation, and the evolution and natural variation of meiotic processes. Four poster sessions, open to all participants throughout the conference will provide a basis for extended and in- depth critical discussions. The poster sessions are a particularly valuable forum for forging interdisciplinary collaborations and for new investigators to join networks. The GRS will include between 50-60 participants and will have three plenary and one poster session. This application has direct relevance to human health. Roughly 58% of human conceptions suffer an error in meiosis that results in miscarriage or birth defects related to chromosomal abnormalities. In addition, many of the mechanisms that repair programmed double strand breaks during meiosis also serve to protect mitotically dividing cells from harmful DNA lesions. Therefore, understanding meiosis provides novel insights into genome stability and preventing cancer. This pair of conferences brings together graduate students, postdocs, young investigators and established PIs to push the leading edge of innovation and knowledge in this critical area of reproductive health.