State University of New York (SUNY) Downstate NETT Clinical Site Hub

纽约州立大学 (SUNY) 州下 NTT 临床站点中心

• 批准号: 8700552
• 负责人: STEVEN Richard LEVINE
• 金额: $ 29.47万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8700552
• 关键词: Acute; Adult; Area; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Community Hospitals; Community Networks; Complex; Conduct Clinical Trials; Critical Care; Data; Disease; Emergency Medicine; Emergency treatment; Epilepsy; Ethics; Faculty; Fire - disasters; Funding; Goals; Health Sciences; Hispanics; Hospitals; Information Technology; Informed Consent; Joints; Leadership; Medical center; Mentors; Minority; Morbidity - disease rate; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Neurology; New York; New York City; Participant; Patients; Pediatric Neurology; Pediatrics; Performance; Pharmacy facility; Phase; Phase II Clinical Trials; Phase III Clinical Trials; Physical Medicine; Physicians; Population; Public Health; Public Hospitals; Radiology Specialty; Randomized; Randomized Clinical Trials; Recording of previous events; Recruitment Activity; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Training; Risk; Seizures; Site; Stroke; Structure; System; Teaching Hospitals; Telemedicine; Training; Training Programs; Trauma; Underrepresented Minority; United States National Institutes of Health; Universities; Visit; Work; base; clinical practice; clinical research site; effective therapy; experience; improved; innovation; mortality; nervous system disorder; neurosurgery; programs; racial and ethnic; success; treatment trial

DESCRIPTION (provided by applicant): The State University of New York (SUNY) Downstate Medical Center has created a Clinical Site Hub and Spoke NETT to join a national clinical research network. Our 5-hospital NETT, included within federally designated underserved areas, serves a large minority population, will conduct clinical trials designed to develop effective treatments for patients with neurological emergencies. Our existing infrastructure of the Hub at SUNY Downstate Medical Center, with joint experienced leadership from Emergency Medicine and Neurology, has established 2 large spokes: Lincoln Hospital (south Bronx), serving primarily Hispanics, and Maimonides Medical Center (Brooklyn), one of the largest independent teaching hospitals in the US. We work collaboratively with investigators and clinicians in critical care, neurosurgery, Trauma, Stroke, and Epilepsy Centers, Neuroradiology, Rehabilitation, Community Engagement/ Disparities Research, Fire Department of New York (FDNY) Pre-Hospital 911 System, Pharmacy, and Information Technology. Our goal is to identify, recruit, and retain a large number of participants from highly diverse backgrounds in high quality clinical research in neurological emergencies using best research practices and the highest ethical standards of research conduct. We will facilitate the transfer of research results to clinical practice via active dissemination of study findings. We are mentoring junior faculty, including minority investigators, in the conduct of phase 3 randomized clinical trials. Our growing infrastructure includes a recently NINDS-funded SUNY NeuroNEXT UIO for phase 2 trials among other formalized and funded research and training programs. This NETT is jointly led by experienced clinical trialists well-versed in complex multi-center administrative structure and projects with established mentoring programs and a growing cadre of acute neurology subspecialists. Our NETT includes a combined annual ED volume of over 350,000 visits, with over 3,500 neurological emergencies. Strengths include the extremely diverse, large patient pool, extensive NIH clinical trials experience, detailed ED visit data from all hospitals, acute telemedicine experience, expertise in exemption from informed consent, and well-established, extensive community networks and engagement.

描述（由申请人提供）：纽约州立大学（SUNY）Downstate医学中心创建了一个临床站点中心和辐条NETT，以加入国家临床研究网络。我们的5家医院NETT，包括在联邦指定的服务不足的地区，服务于大量的少数民族人口，将进行临床试验，旨在为神经系统紧急情况的患者开发有效的治疗方法。我们现有的基础设施， 纽约州立大学Downstate医疗中心的中心，与急诊医学和神经病学的经验丰富的领导人联合，建立了两个大型辐条：林肯医院（南布朗克斯），主要为西班牙裔服务，迈蒙尼德医疗中心（布鲁克林），美国最大的独立教学医院之一。我们与重症监护、神经外科、创伤、中风和癫痫中心、神经放射学、康复、社区参与/差异研究、纽约消防局（FDNY）院前911系统、药房和信息技术的研究人员和临床医生合作。我们的目标是使用最佳研究实践和研究行为的最高道德标准，在神经系统紧急情况的高质量临床研究中识别，招募和保留大量来自高度多样化背景的参与者。我们会透过积极传播研究结果，促进研究成果转化为临床实践。我们正在指导初级教师，包括少数民族研究者，进行3期随机临床试验。我们不断增长 基础设施包括最近NINDS资助的SUNY NeuroNEXT UIO，用于其他正式和资助的研究和培训计划中的2期试验。该NETT由经验丰富的临床试验专家共同领导，他们精通复杂的多中心管理结构和项目，具有既定的指导计划和不断增长的急性神经病学亚专家骨干。我们的NETT包括超过350，000次访问的合并年度艾德量，超过3，500次神经系统紧急情况。优势包括极其多样化的大型患者库、广泛的NIH临床试验经验、来自所有医院的详细艾德访视数据、急性远程医疗经验、豁免知情同意的专业知识以及完善的广泛社区网络和参与。