Investigation and therapeutic targeting of the immune mechanisms that predispose to and increase the severity of influenza in pregnancy

在怀孕期间，抑制母体免疫以使胎儿着床和生长。呼吸道病毒，如流感，利用这些变化，在孕妇中引起更严重的感染，影响她们和她们的婴儿。在这个项目中，我们的目标是确定针对怀孕期间减少的病毒的特定免疫反应，这些免疫反应可以选择性地增强。这有可能在不影响怀孕或婴儿的情况下预防病毒。

In pregnancy there is suppression of maternal immunity to enable fetal implantation and growth. Respiratory viruses, like influenza, take advantage of these changes and cause infections that are more severe in pregnant women, affecting them and their babies. In this project we aim to identify specific immune responses against viruses that are reduced in pregnancy that can be selectively boosted. This has the potential to protect against viruses without affecting the pregnancy or baby.