FASEB SRC on Molecular Mechanisms and Physiological Consequences of Protein Aggregation

FASEB SRC 关于蛋白质聚集的分子机制和生理后果

• 批准号: 8910849
• 负责人: Matthew Richard Chapman
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8910849
• 关键词: Address; Affect; Alzheimer' s Disease; Amyloid; Amyloid deposition; Amyloidosis; Area; Biochemical; Biological Models; Biological Phenomena; Bovine Spongiform Encephalopathy; Brain; Cell physiology; Cells; Complex; Development; Diagnostic; Disease; Disease Progression; Economic Burden; Employee Strikes; Etiology; Event; Extracellular Matrix; Familial Amyloid Neuropathies; Florida; Fostering; Goals; Hormones; Human; Huntington Disease; In Vitro; Individual; Link; Modeling; Molecular; Nature; Nerve Degeneration; Non-Insulin-Dependent Diabetes Mellitus; Organelles; Parkinson Disease; Participant; Pathology; Pathway interactions; Physicians; Physiological; Physiology; Prion Diseases; Process; Proteins; Publications; Quality Control; Research; Research Personnel; Scientist; Series; Structural Biologist; Synapses; System; Therapeutic; Thermodynamics; Triage; Ursidae Family; Work; amyloid formation; amyloid structure; amyloidogenesis; beta-2 Microglobulin; biophysical properties; cell type; design; effective therapy; experience; flexibility; human disease; in vivo; innovation; mathematical model; nervous system disorder; programs; protein aggregate; protein aggregation; protein folding; protein misfolding; public health relevance; symposium

 DESCRIPTION (provided by applicant): While amyloid has long been the hallmark of many neurological diseases, the precise molecular pathways governing amyloid formation, the causality of these events in disease initiation and progression, and the sensitivity of these processes to therapeutic disruption, remain significant open questions that are the subject of aggressive research. This R13 proposal seeks core support for a FASEB Summer Research Conference on "Molecular Mechanisms and Physiological Consequences of Protein Aggregation." The tenth conference in a series that began in 1995, our program seeks to leverage the breadth of proteins, systems, and approaches available to advance our understanding of the full range of biological phenomena linked to amyloidogenesis with the goal of ultimately intervening in these processes. The conference will be held in Palm Beach, FL on June 21-26, 2015, will provide a forum for the presentation and discussion of newly arising advances and for establishing collaborative relationships to address the grand challenges in the field. The small size (typically 150 participants) of this conference and its innovative representation of the full range of research on amyloidogenesis provides a unique opportunity to capture and integrate the complexity of this process and synergistically advance the field.

 描述（由申请人提供）：虽然淀粉样蛋白长期以来一直是许多神经系统疾病的标志，但控制淀粉样蛋白形成的精确分子途径、这些事件在疾病发生和进展中的因果关系以及这些过程对治疗干扰的敏感性仍然是重要的悬而未决的问题，也是积极研究的主题。该 R13 提案寻求对 FASEB 夏季研究会议“蛋白质聚集的分子机制和生理后果”的核心支持。这是自 1995 年开始的系列会议的第十次，我们的计划旨在利用广泛的蛋白质、系统和方法来促进我们对与淀粉样蛋白生成相关的全方位生物现象的理解，以最终干预这些过程。该会议将于 2015 年 6 月 21 日至 26 日在佛罗里达州棕榈滩举行，将为展示和讨论新出现的进展以及建立合作关系以应对该领域的重大挑战提供一个论坛。本次会议的规模较小（通常为 150 名与会者），其对淀粉样蛋白生成全方位研究的创新表述为捕捉和整合这一过程的复杂性并协同推进该领域提供了独特的机会。