Investigation of a virulence locus on chromosome 9 of Plasmodium falciparum utilising improved transfection technology

利用改进的转染技术研究恶性疟原虫 9 号染色体上的毒力位点

• 批准号: nhmrc : 137211
• 负责人: A/Pr Donald Gardiner
• 金额: $ 14.1万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-virulence-locus-transfection-technology/99501
• 关键词: Investigation; virulence; locus; chromosome; Plasmodium

Worldwide, there are approximately 500 million cases of malaria per year with over 1 million deaths, predominately in children under 5 years of age in Africa. We have identified a region of the malaria parasites' genome that we believe is responsible for two aspects of the parasites life cycle. Firstly, there is a gene responsible for the development of the sexual stage of the parasite that allows transmission from humans to mosquitoes and secondly there are two other genes that allow the parasite to evade the human hosts immune system. We intend to investigate these genes using newly developed genetic engineering tools with the ultimate aim of finding agents or vaccines that can block their action, thus preventing either transmission of the parasite or the severe effects of infection.

全球每年约有 5 亿例疟疾病例，导致超过 100 万人死亡，其中主要是非洲 5 岁以下儿童。我们已经确定了疟疾寄生虫基因组的一个区域，我们认为该区域负责寄生虫生命周期的两个方面。首先，有一个基因负责寄生虫有性阶段的发育，允许从人类传播给蚊子；其次，还有另外两个基因可以让寄生虫逃避人类宿主的免疫系统。我们打算使用新开发的基因工程工具来研究这些基因，最终目的是找到可以阻止其作用的药物或疫苗，从而防止寄生虫的传播或感染的严重影响。