Plasmodium falciparum neutral aminopeptidases: structure-function analysis for the discovery of anti-malarial drugs.

恶性疟原虫中性氨肽酶：用于发现抗疟​​疾药物的结构功能分析。

• 批准号: nhmrc : 571917
• 负责人: A/Pr Donald Gardiner
• 金额: $ 42.28万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/plasmodium-falciparum-neutral-malarial-drugs/77245
• 关键词: Plasmodium; falciparum; neutral; aminopeptidases; structure

Malaria is the world's most prevalent parasitic disease. Due to the spread of drug resistant parasites there is an urgent need to identify new anti-malaria targets and develop new drugs. We have shown that two enzymes, termed neutral aminopeptidases, are essential to the parasite's survival in the host. In this proposal we will obtain the structure of these enzymes and bring forth novel lead compounds that will form the basis of a new class of anti-malaria treatment.

疟疾是世界上最普遍的寄生虫病。由于抗药性寄生虫的传播，迫切需要确定新的抗疟疾靶点并开发新药。我们已经表明，两种酶，称为中性氨肽酶，是必不可少的寄生虫在宿主中的生存。在这项提案中，我们将获得这些酶的结构，并提出新的先导化合物，这些化合物将成为一类新的抗疟疾治疗的基础。