Core E: Imaging

核心E：成像项目总结 结构MR和淀粉样蛋白PET成像已经由国家老龄化研究所提出作为以下方法： 将临床前阿尔茨海默病（AD）细分为（1）淀粉样变性，随后是（2） 淀粉样变性加神经变性，两者都先于（3）微妙的认知下降，随后是临床 进展为轻度认知障碍（MCI）和AD痴呆。HASD成像核心将提供MR 以及PET对HASD项目的支持，以测试这些拟议阶段与正常到 认知能力受损（项目1）、睡眠障碍（项目2）和遗传分析（项目3）。 将追求以下具体目标： I. PET-MR联合扫描用于脑结构、功能和淀粉样病变。对于整个组合 HASD和ADRC队列，我们将每三个月进行一次脑MRI和florbetapir F18（AV 45）淀粉样蛋白成像 年（200人/年）。 二.为这些成像测试提供数据处理，以包括（2a）匹配的区域体积、厚度，以及 定量PET分析，（2b）定量个体纵向参与者报告，比较规范性 （2c）根据从群组产生的分类对区域报告进行分组， 项目和核心。 三.生成包含源成像（DICOM）、已处理成像和 临床和生物标志物表征，以促进我们机构以外的数据共享，包括 对JC Morris、HASD PI和T. Benzinger，HASD 图像核心负责人，Avid/Lilly。这种伙伴关系允许纵向MR和淀粉样蛋白PET的资金 整个队列的成像。

Core E: Imaging Project Summary Structural MR and amyloid PET imaging have been proposed by the National Institute on Aging as methods to subdivide preclinical Alzheimer Disease (AD) into discrete stages of (1) amyloidosis, followed by (2) amyloidosis plus neurodegeneration, both of which precede (3) subtle cognitive decline, followed by the clinical progression to mild cognitive impairment (MCI) and AD dementia. The HASD Imaging Core will provide MR and PET support to the HASD Projects to test how these proposed stages relate to the transition for normal to impaired cognitive performance (Project 1), sleep disturbance (Project 2), and genetic analyses (Project 3). The following Specific Aims will be pursued: I. Combined PET-MR scanning for brain structure, function, and amyloid pathology. For the entire combined HASD and ADRC cohorts, we will perform brain MRI and florbetapir F18 (AV45) amyloid imaging every three years (200 participants/year). II. Provide data processing for these imaging tests, to include (2a) matched regional volumes, thicknesses, and quantitative PET analyses, (2b) quantitative individual longitudinal participant reports compared normative values generated by the cohort, and (2c) grouped regional reports based on classifications derived from the Projects and Cores. III. Generate an online accessible resource containing source imaging (DICOM), processed imaging, and clinical and biomarker characterization to facilitate data sharing outside of our institution, including contributions to the private-public partnership developed by JC Morris, HASD PI, and T. Benzinger, HASD Imaging Core Leader, with Avid/Lilly. This partnership allows funding for longitudinal MR and amyloid PET imaging for the entire cohort.