Imaging Core
Imaging Core
批准号:
8425006
负责人:
Tammie Lee Smith Benzinger
金额:
$74.06万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31
关键词:
Alzheimer&aposs DiseaseAmyloidAmyloid ProteinsAmyloid beta-ProteinAmyloid depositionAnatomyArchivesBindingBinding SitesBiochemicalBiologicalBiological MarkersBrainBrain InjuriesBrain imagingCellsClinicalCollectionDataData SetDatabasesDecision MakingDementiaDepositionDiseaseEvaluationFunctional disorderGenerationsGoalsHandHeadImageImage AnalysisImaging TechniquesIndividualInformaticsInheritedInterventionLate Onset Alzheimer DiseaseMagnetic Resonance ImagingMeasuresMetabolicMetabolismMorphologic artifactsNeuronal DysfunctionNeuronsNoiseParticipantPositron-Emission TomographyProceduresProcessProtocols documentationPsychometricsQualifyingQuality ControlQuarantineRecruitment ActivityRelative (related person)Research PersonnelResolutionRoleScanningSenile PlaquesSeriesSignal TransductionSiteStagingStandardizationTestingTimeWorkabeta accumulationbrain tissuebrain volumedensitydesignglucose metabolismgray matterimage processinginsightinterestneuroimagingpre-clinicalrelating to nervous system
中文摘要
我们假设阿尔茨海默病(AD)有一个临床前阶段,在这个阶段中大脑水平升高
淀粉样蛋白和β-淀粉样沉积的堆积预示着神经元的逐渐发病
功能障碍、细胞丢失和痴呆症。虽然淀粉样蛋白在启动脑损伤中的确切作用仍然是
尚不清楚,澄清AD之前淀粉样蛋白沉积的确切时间将对
了解阿尔茨海默病的生物学起源,并设计适当的干预措施。脑成像提供了
了解AD中许多假想的生化、功能和解剖变化的窗口。用正电子
使用[11C]PIB的发射断层扫描(PET)可以通过以下方法估计β-淀粉样斑块的密度
成像PIB结合部位。对于使用[18F]FDG的PET,有可能从
代谢活动的衡量标准。最后,使用磁共振成像(MRI),随着时间的推移,体积损失可以
在区域和全球大脑测量中进行量化。我们的前提是,通过考察时间和
这三个度量之间的空间相互关系将在
阿尔茨海默病的病理生理学。
通过将数据与脑脊液生物标记物相结合,这些成像生物标记物的价值进一步增强
以及临床和心理测量数据。为了实现这些目标,成像核心将提供两个关键支持
DIAN工作的活动:目标1:监督所有图像数据的收集。这些数据包括磁共振扫描
对于形态计量学,PET FDG扫描新陈代谢,PET PIB扫描成像β淀粉样斑块。
目标2:进行图像处理和分析,以从图像数据中提取与生物相关的测量
准备好了。这些测量包括全脑体积以及皮质和皮质下区域的灰度值。
物质体积、相对葡萄糖代谢和PIB得出的β-淀粉样斑块沉积的估计。
英文摘要
We hypothesize that Alzheimer's disease (AD) has a preclinical stage in which elevated levels of brain
amyloid protein and accumulation of beta-amyloid deposits foreshadow the gradual onset of neuronal
dysfunction, cell loss and dementia. While the exact role of amyloid in the initiation of brain damage is still
unclear, clarifying the exact timing of amyloid deposition that precede AD would be extremely helpful in
understanding the biological origins of AD and in designing appropriate interventions. Brain imaging provides
a window into many of the hypothesized biochemical, functional and anatomic changes in AD. With Positron
Emission Tomography (PET) using [11C]PIB it is possible to estimate the density of beta-amyloid plaques by
imaging the PIB binding sites. With PET using [18F]FDG it is possible to estimate neuronal function from
measures of metabolic activity. Finally, with magnetic resonance imaging (MRI) volume loss over time can
be quantified in regional and global brain measures. It is our premise that by examining the temporal and
spatial interrelationships between these three measures important insights will be gained in the
pathophysiology of AD.
The value of these imaging biomarkers are further enhanced by combining the data with CSF biomarkers
and clinical and psychometric data. Towards these goals, the Imaging Core will provide two key support
activities to the DIAN effort: Aim 1: Oversee the collection of all image data. This data includes MR scans
for morphometrics, PET FDG scans for metabolism and PET PIB scans for imaging beta-amyloid plaques.
Aim 2: Perform image processing and analysis to extract biologically relevant measures from the image data
set. These measures include whole brain volume and cortical and subcortical regional measures of gray
matter volume, relative glucose metabolism and PIB-derived estimates of beta-amyloid plaque deposition.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Translational Imaging Research Program in Radiopharmaceutical Sciences
-
批准号:10687184
-
项目类别:
-
资助金额:$51.27万
-
财政年份:2022
-
负责人:Tammie Lee Smith Benzinger
-
依托单位:
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSIS
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批准号:10226102
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项目类别:
-
资助金额:$59.45万
-
财政年份:2017
-
负责人:Tammie Lee Smith Benzinger
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依托单位:
Quantification of Neuroinflammation inAlzheimer's Disease Using Diffusion BasisSpectrum Imaging
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批准号:10192620
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项目类别:
-
资助金额:$68.98万
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财政年份:2017
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负责人:Tammie Lee Smith Benzinger
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依托单位:
PET Sphingosine-1-Phosphate Receptor 1 (S1P1) radiotracer for inflammation response in multiple sclerosis
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批准号:10660824
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项目类别:
-
资助金额:$64.09万
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财政年份:2017
-
负责人:Tammie Lee Smith Benzinger
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依托单位:
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSIS
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批准号:9973243
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项目类别:
-
资助金额:$60.33万
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财政年份:2017
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Antecedent Neuroimaging Biomarkers
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批准号:8287324
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项目类别:
-
资助金额:$36.7万
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财政年份:2011
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Dominantly Inherited Alzheimer Network: Imaging Core
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批准号:10017838
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项目类别:
-
资助金额:$83.6万
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财政年份:2008
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Dominantly Inherited Alzheimer Network: Imaging Core
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批准号:10225485
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项目类别:
-
资助金额:$120.37万
-
财政年份:2008
-
负责人:Tammie Lee Smith Benzinger
-
依托单位:
Dominantly Inherited Alzheimer Network: Imaging Core
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批准号:10462562
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项目类别:
-
资助金额:$95.31万
-
财政年份:2008
-
负责人:Tammie Lee Smith Benzinger
-
依托单位:
Dominantly Inherited Alzheimer Network: Imaging Core
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批准号:10665740
-
项目类别:
-
资助金额:$115.1万
-
财政年份:2008
-
负责人:Tammie Lee Smith Benzinger
-
依托单位:
Antecedent Neuroimaging Biomarkers
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批准号:8522090
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项目类别:
-
资助金额:$4.43万
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财政年份:2005
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Core E: Imaging Core
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批准号:10396448
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项目类别:
-
资助金额:$128.24万
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财政年份:1997
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Core E: Imaging Core
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批准号:10622494
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项目类别:
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资助金额:$133.76万
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财政年份:1997
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Antecedent Neuroimaging Biomarkers
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批准号:8381834
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项目类别:
-
资助金额:$33.29万
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财政年份:--
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Core E: Imaging
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批准号:9265731
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项目类别:
-
资助金额:$41.96万
-
财政年份:--
-
负责人:Tammie Lee Smith Benzinger
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依托单位:
Antecedent Neuroimaging Biomarkers
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批准号:8522092
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项目类别:
-
资助金额:$40.0万
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财政年份:--
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Core E: Imaging Core
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批准号:9914184
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项目类别:
-
资助金额:$118.06万
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财政年份:--
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Core E: Imaging
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批准号:8903785
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项目类别:
-
资助金额:$27.9万
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财政年份:--
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Antecedent Neuroimaging Biomarkers
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批准号:8732596
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项目类别:
-
资助金额:$40.04万
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财政年份:--
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负责人:Tammie Lee Smith Benzinger
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依托单位:
Dominantly Inherited Alzheimer Network: Imaging Core
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批准号:9790618
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项目类别:
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资助金额:$86.34万
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财政年份:--
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负责人:Tammie Lee Smith Benzinger
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依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
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批准号:81000622
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项目类别:青年科学基金项目
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资助金额:20.0万元
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批准年份:2010
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负责人:梁胜
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依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
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批准号:31060293
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项目类别:地区科学基金项目
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资助金额:26.0万元
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批准年份:2010
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负责人:郭亚芬
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依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究
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批准号:30960334
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项目类别:地区科学基金项目
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资助金额:22.0万元
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批准年份:2009
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负责人:董贵成
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依托单位: