Investigations on copper regulated trafficking of Amyloid Precursor Protein of Alzheimer's Disease

铜调节阿尔茨海默病淀粉样前体蛋白运输的研究

• 批准号: nhmrc : 1030578
• 负责人: Prof James Camakaris
• 金额: $ 19.75万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigations-copper-regulated-alzheimers-disease/110763
• 关键词: Investigations; copper; regulated; trafficking; Amyloid

Sufferers of Alzheimer's disease have excessive levels of a particular protein (Abeta) as well as a copper imbalance in the brain. It is widely accepted that high Abeta content contributes to the onset of Alzheimer's disease. Copper imbalance in the brain also plays a major role in the pathology of the disease. This research aims to investigate the interplay between copper and the protein which gives rise to Abeta, with the view to developing targeted treatments for Alzheimer's patients.

阿尔茨海默病患者有一种特定的蛋白质（Abeta）水平过高，以及大脑中铜的不平衡。普遍认为高Abeta含量有助于阿尔茨海默病的发作。大脑中的铜不平衡也在疾病的病理学中起着重要作用。这项研究旨在研究铜与产生Abeta的蛋白质之间的相互作用，以期为阿尔茨海默病患者开发有针对性的治疗方法。