Novel Echocardiographic Methods to Characterize Heart Failure in ESRD

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 DESCRIPTION (provided by applicant): The current paradigm for heart failure in the general population does not adequately describe the spectrum of cardiac disease in patients with end-stage renal disease (ESRD). Most patients with ESRD have normal left ventricular ejection fraction and mildly impaired diastolic function, as measured by conventional echocardiographic methods. This information suggests that most patients with ESRD have low risk for heart failure. In fact, patients on dialysis have an extremely high rate of heart failure and cardiovascular mortality. We believe that modern methods of echocardiography will capture a broader range of systolic and diastolic function in this population, and thus provide better insight into cardiac function and risk. Another challenge in studying heart failure in this population is the impact tha hemodialysis-related changes in volume status have on cardiac function. The aim of this study is to collect echocardiographic data with consistent timing relative to hemodialysis, using two novel methods. Ventricular chamber elastance (stiffness) is a novel parameter that can be calculated non-invasively using quantitative analysis of conventional echocardiographic images, and is thought to be independent of loading conditions. Speckle tracking echocardiography is a state-of-the-art imaging and analysis modality that captures incremental deformation of individual cardiac segments during systole and diastole and thus is a measure of intrinsic myocardial mechanics as opposed to global cardiac chamber measurements (such as ejection fraction) that depend on ventricular volumes. Echocardiography will be performed in an ESRD cohort that is being recruited as part of a K23 Award focused on vascular dysfunction in ESRD. We will study 200 participants on hemodialysis; patients will be studied the day after their first dialysis session of the week. Twenty of the patients will also be studied on a dialysis day, directly before and after dialysis, to test the hypothesis that novel echo parameters will vary les during dialysis than traditional, volume-dependent parameters. We will rigorously adjudicate heart failure hospitalizations distinct from hospitalizations due to medical non-compliance or missed dialysis. We will compare the performance of novel and conventional echocardiography for predicting two-year heart failure hospitalizations and overall mortality.