Neurobehavioral Assessment of Reward Sensitivity in Young Smokers

年轻吸烟者奖励敏感性的神经行为评估

基本信息

批准号：
8890611
负责人：
Francesco Versace
金额：
$ 24万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8890611
关键词：
Abstinence Accounting Adolescence Affect Anhedonia Behavioral Biological Markers Brain Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Cigarette Clinical Data Dependence Development Diagnostic Procedure Disease Drug Addiction Drug usage Electroencephalogram Event Event-Related Potentials Evidence based intervention Exploratory/Developmental Grant Goals Individual Individual Differences Intervention Link Measures Mediating Mission National Institute of Drug Abuse Neurobiology Nicotine Nicotine Dependence Outcome Patient Self-Report Performance Pharmaceutical Preparations Phenotype Play Prevention strategy Procedures Process Public Health Reporting Research Rewards Risk Role Smoker Smoking Social Desirability Stimulus Substance abuse problem Testing Time Tobacco Dependence Tobacco use United States United States Substance Abuse and Mental Health Services Administration Variant Youth addiction base behavior measurement brain behavior cigarette smoking cost design drug of abuse evidence base experience hedonic high risk indexing innovation interest neurobehavioral neurophysiology never smoker prevent public health relevance reinforcer relating to nervous system response reward processing smoking cessation stem success successful intervention twelfth grade voltage young adult

项目摘要

DESCRIPTION (provided by applicant): Several factors contribute to nicotine dependence, but dysregulation of brain circuits underlying reward sensitivity play a fundamental role. Chronic drug use is thought to result in the attribution of excessive motivational value to drugs at the expense of natural rewards. The neurobiological processes mediating reduced sensitivity to natural rewards are still obscure. We do not know whether brain reward sensitivity differences are already present in young smokers or whether these differences develop only after long-term nicotine use. Furthermore, we do not yet know how brain reward sensitivity differences are related to behavioral and subjective measures of hedonic capacity (i.e., the tendency to not enjoy pleasurable activities). The objective of this application is to assess the feasibility of usng a newly discovered neural biomarker to characterize youths' individual differences in reward sensitivity. Our central hypothesis is that young smokers will already show blunted brain responses to natural rewards and that these differences will correlate with behavioral and self- report measures of hedonic capacity. To test this hypothesis we will assess reward sensitivity in young smokers and never smokers using dense array event-related potentials (ERPs), behavioral, and self-report measures. This multi-modal approach will allow us to link subjective and behavioral variation in hedonic capacity to its neural underpinnings. We will achieve our objective by pursuing the following Specific Aims: 1) Characterize in young smokers the behavioral correlates of brain reward sensitivity; 2) Determine the role exerted by nicotine on youths' reward sensitivity. Our approach is innovative because the multimodal assessment proposed here will allow us to investigate the relationships existing among neurobiological, behavioral, and subjective domains of the reward-processing construct and to determine how nicotine alters them in young smokers. Determining in youths how neural, behavioral, and subjective measures of reward sensitivity interrelate is significant because it is the necessary preliminary step to understanding how individual differences in hedonic capacity confer vulnerability to nicotine dependence. The results of this project will contribute to the development of new and effective evidence-based prevention strategies for individuals at risk, and to the creation of more successful interventions to promote abstinence in individuals already addicted.

描述（由适用提供）：有几个因素导致尼古丁依赖性，但是对奖励灵敏度的脑回路失调起着基本作用。人们认为，长期使用药物的使用会导致过多的动机价值以牺牲自然奖励为代价。介导降低自然奖励敏感性的神经生物学过程仍然晦涩难懂。我们不知道大脑奖励敏感性差异是否已经存在于年轻吸烟者中，还是仅在长期使用尼古丁后才出现这些差异。此外，我们尚不知道大脑奖励敏感性差异如何与享乐能力的行为和主体度量有关（即，不享受愉快的活动的趋势）。该应用的目的是评估USNG新发现的神经生物标志物的可行性，以表征青年人在奖励中的个体差异。灵敏度。我们的中心假设是，年轻的吸烟者已经表现出对自然奖励的大脑反应，这些差异将与享乐能力的行为和自我报告量相关。为了检验这一假设，我们将使用密集的阵列事件相关电位（ERP），行为和自我报告措施来评估年轻吸烟者的奖励敏感性，而从未吸烟。这种多模式方法将使我们能够将享乐能力的主观和行为变化与其神经基础联系起来。我们将通过追求以下特定目标来实现我们的目标：1）在年轻吸烟者中表征大脑奖励灵敏度的行为相关性； 2）确定尼古丁对青年奖励灵敏度的作用。我们的方法具有创新性，因为这里提出的多模式评估将使我们能够研究奖励处理结构的神经生物学，行为和主题领域之间存在的关系，并确定尼古丁在年轻吸烟者中如何改变它们。确定年轻人中的中立，行为和主观衡量奖励灵敏度如何相互关联是重要的，因为这是了解享乐主义能力中个体差异的必要初步步骤。该项目的结果将有助于制定有效的有风险个人的新的和有效的基于证据的预防策略，并创建更成功的干预措施，以促进已经上瘾的个人的禁欲。