Methamphetamine Research Program at Meharry Medical College

描述（由申请人提供）：本申请中描述的拟议DIDARP项目的长期目标是继续提高梅哈里医学院在物质使用障碍方面进行严格研究的能力，重点是健康差异和服务不足的人群。该研究计划将寻求了解急性和慢性甲基苯丙胺（甲基安非他明）单独暴露以及与人类免疫缺陷病毒（HIV）感染相结合的分子基础。我们亦计划加强我们的智力环境，提高学员和教员对药物滥用研究的兴趣。这项申请的新内容是建议对家庭和社区医学诊所的医学生、住院医生和教员进行药物滥用筛查和简短干预方面的培训。梅哈里医学院DIDARP项目在未来五年内的具体目标是：1。在药物滥用研究领域的高影响力期刊上发表至少20篇经同行评审的论文；2. 在资助期内的第三年度提交5个或以上的药物滥用研究资助申请；| 3。在2005年底前获得3个或以上的研究人员发起的奖励；和4。通过加强课程、研讨会和专题讨论会，激发更多教员和学员对药物滥用研究的兴趣。提出了三个项目，一个主要项目和两个试点项目。在主要项目中，CV博士。Dash将试图了解滥用冰毒和感染艾滋病毒之间的联系。在第一个试点项目中，j·肖恩·古德温（J. Shawn Goodwin）博士将研究滥用冰毒如何通过改变脂筏中的多巴胺转运体来改变多巴胺信号。在第二个试点项目中，Khilber博士和她的合作者，包括PI和家庭和社区医学主席Roger Zoorob博士，将测试一个分层培训计划对药物滥用的筛查，短暂干预和转诊治疗（SBIRT）的效果

DESCRIPTION (provided by applicant): The long-range goal of the proposed DIDARP program described in this application is to continue to increase the capacity of Meharry Medical College to conduct rigorous research in substance use disorders with an [ emphasis on health disparities and underserved populations. The research program will seek to understand the molecular underpinnings of acute and chronic methamphetamine (METH) exposure alone and in conjunction with human immunodeficiency virus (HIV) infection. We also plan to strengthen pur intellectual environment and enhance the interest levels of trainees and faculty in drug abuse research. New for this j application is the proposal to introduce training on screening and brief interventions for substance misuse to medical students, residents and faculty in the Family and Community Medicine clinics. The Specific Aims of the Meharry Medical College DIDARP Program during the next five years are: 1. To publish at least 20 or more peer-reviewed publications in high-impact journals in drug abuse research; 2. To submit 5 or more grant applications in drug abuse research by Year-03 of the award period; | 3. To acquire 3 or more investigator-initiated awards by the end of year-05; and 4. To stimulate additional faculty and trainee interest in drug abuse research by curricula enhancement, ' seminars and symposia. . Three projects are proposed, one primary proposal and two pilot projects. In the primary project, Dr. CV. ] Dash will seek to understand the link between METH abuse and HIV infection. In the first pilot project, Dr. J. Shawn Goodwin will study how METH abuse alters dopamine signaling by altering the dopamine transporter residency in lipid rafts. In second pilot project, Dr. Khilber and her collaborators which includes the PI and the Chair of Family and Community Medicine, Dr. Roger Zoorob, will test the effects of a tiered training program on screening, brief intervention and referral to treatment (SBIRT) for substance misuse fo