Methamphetamine Research Program at Meharry Medical College

描述(由申请人提供)：本申请中描述的拟议DIDARP计划的长期目标是继续提高Meharry医学院在物质使用障碍方面进行严格研究的能力，[重点是健康差距和服务不足的人群]。该研究计划将寻求了解急性和慢性接触甲基苯丙胺(冰毒)以及与人类免疫缺陷病毒(HIV)感染一起的分子基础。我们还计划加强PUR知识环境，提高学员和教职员工对药物滥用研究的兴趣。这项j申请的新建议是向家庭和社区医学诊所的医学生、住院医生和教职员工介绍关于药物滥用的筛查和简要干预的培训。Meharry医学院DIDARP计划在未来五年的具体目标是：1.在药物滥用研究的高影响力期刊上发表至少20篇或更多同行评议的论文；2.在获奖期的03年前提交5份或更多关于药物滥用研究的拨款申请；|3.在05年度结束前获得3项或更多由研究人员发起的奖项；以及4.通过课程改进、研讨会和研讨会激发更多教师和实习生对药物滥用研究的兴趣。。提出了三个项目，一个初步建议和两个试点项目。在主要项目中，CV博士。]达什将寻求了解冰毒滥用和艾滋病毒感染之间的联系。在第一个试点项目中，J·肖恩·古德温博士将研究冰毒滥用如何通过改变脂筏中的多巴胺转运体来改变多巴胺信号。在第二个试点项目中，KHilber博士和她的合作者，包括PI和家庭和社区医学主席Roger Zoorob博士，将测试分级培训计划对药物滥用的筛查、短暂干预和转诊治疗(SBIRT)的效果

DESCRIPTION (provided by applicant): The long-range goal of the proposed DIDARP program described in this application is to continue to increase the capacity of Meharry Medical College to conduct rigorous research in substance use disorders with an [ emphasis on health disparities and underserved populations. The research program will seek to understand the molecular underpinnings of acute and chronic methamphetamine (METH) exposure alone and in conjunction with human immunodeficiency virus (HIV) infection. We also plan to strengthen pur intellectual environment and enhance the interest levels of trainees and faculty in drug abuse research. New for this j application is the proposal to introduce training on screening and brief interventions for substance misuse to medical students, residents and faculty in the Family and Community Medicine clinics. The Specific Aims of the Meharry Medical College DIDARP Program during the next five years are: 1. To publish at least 20 or more peer-reviewed publications in high-impact journals in drug abuse research; 2. To submit 5 or more grant applications in drug abuse research by Year-03 of the award period; | 3. To acquire 3 or more investigator-initiated awards by the end of year-05; and 4. To stimulate additional faculty and trainee interest in drug abuse research by curricula enhancement, ' seminars and symposia. . Three projects are proposed, one primary proposal and two pilot projects. In the primary project, Dr. CV. ] Dash will seek to understand the link between METH abuse and HIV infection. In the first pilot project, Dr. J. Shawn Goodwin will study how METH abuse alters dopamine signaling by altering the dopamine transporter residency in lipid rafts. In second pilot project, Dr. Khilber and her collaborators which includes the PI and the Chair of Family and Community Medicine, Dr. Roger Zoorob, will test the effects of a tiered training program on screening, brief intervention and referral to treatment (SBIRT) for substance misuse fo