Variance in sibling mothering received and adult mothering, anxiety and serotonin

兄弟姐妹养育和成人养育、焦虑和血清素的差异

基本信息

  • 批准号:
    8763875
  • 负责人:
  • 金额:
    $ 5.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-08-01 至 2015-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Variance in sibling mothering received and adult mothering, anxiety and serotonin The long-term objectives of this NRSA proposal are to identify how variance among siblings in maternal care received influences mechanisms related to later sibling differences in: 1) maternal behavior, 2) anxiety-like behaviors, and 3) serotonin synthesis and release. This research is novel and important because in humans and non-human animals, it is well-known that variance in maternal care received greatly differs between families and has tremendous effects on offspring neurological and social development, yet studies examining this phenomenon within families are scarce. Using a rat model, I will examine the association between mother- infant interactions during the early postnatal period and adult mothering, anxiety-related behaviors, and serotonin activity among sisters. In Specific Aim 1, I will conducted finely detailed observations of maternal care received during the first ten days of life and determine if high-licked females provide more maternal care to their own offspring compared to their low-licked sisters. During adulthood, these females will also be tested on the elevated plus maze (a well-validated measure of anxiety-like behavior in rodents) to determine if differences in anxiety are associated with their differences in mothering. In Specific Aim 2, I wil use Western Blots to measure expression of tryptophan hydroxylase 2 (TPH2, the major enzyme responsible for brain serotonin synthesis) in the dorsal raphe with the hypothesis that it is upregulated in high-licked females compared to their low-licked sisters. Finally, in Specific Aim 3, I will determine if serotonin release in the ventral bed nucleus of the stria terminalis (BSTv), an area receiving dense serotonergic projections from the DR and associated with maternal behavior and anxiety, is higher in high-licked females than their low-licked sisters. To accomplish this, I will use in vivo microdialysis to measure serotonin release in the BSTv in postpartum sisters while they interact with pups. In a second experiment in this Aim, I will determine if variability among sisters in mothering can be minimized by administration of the 5-HT1a receptor agonist, flesinoxan, to low-licked sisters. In this proposal, I aim to clarify early perinatal predictors of individual differences in anxiety-related and mothering behaviors, which will promote a better understanding of developmental trajectories leading women toward risk for adult anxiety disorders.
描述(由申请人提供):兄弟姐妹接受的母亲照顾和成人母亲照顾的差异,焦虑和5-羟色胺NRSA提案的长期目标是确定兄弟姐妹接受母亲照顾的差异如何影响与后来兄弟姐妹差异相关的机制:1)母亲行为,2)焦虑样行为,3)5-羟色胺合成 然后释放这项研究是新颖和重要的,因为在人类和非人类动物中,众所周知,家庭之间获得的孕产妇护理差异很大,对后代的神经和社会发展有巨大影响,但研究家庭内这种现象的研究很少。使用大鼠模型,我将研究在出生后早期的母亲-婴儿之间的相互作用和成年母亲,焦虑相关的行为,和姐妹篇之间的血清素活性之间的关联。在具体目标1中,我将对出生后10天内所接受的母性关怀进行细致的观察,并确定高舔率的雌性是否比低舔率的姐妹篇对自己的后代提供更多的母性关怀。在成年期,这些女性还将在高架十字迷宫(一种经过充分验证的啮齿动物焦虑样行为的测量方法)上进行测试,以确定焦虑的差异是否与其育儿差异有关。在具体目标2中,我将使用蛋白质印迹法来测量色氨酸羟化酶2(TPH 2,负责大脑5-羟色胺合成的主要酶)在中缝背核中的表达,假设它在高舔女性中上调,而不是他们的低舔姐妹篇。最后,在具体目标3中,我将确定是否在终纹腹侧床核(BSTv)中的5-羟色胺释放,这是一个接受来自DR的密集多巴胺能投射并与母性行为和焦虑相关的区域,在高舔女性中高于低舔姐妹篇。为了实现这一点,我将使用体内微透析来测量产后姐妹篇与幼崽互动时BSTv中的5-羟色胺释放。在本目标的第二个实验中,我将确定是否可以通过给予5-HT 1a受体激动剂flesinoxan来最大限度地减少姐妹篇之间在母性方面的差异。在这项提案中,我的目标是澄清焦虑相关和育儿行为的个体差异的早期围产期预测因素,这将促进更好地了解导致女性患成人焦虑症风险的发展轨迹。

项目成果

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Christina Ragan其他文献

Christina Ragan的其他文献

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{{ truncateString('Christina Ragan', 18)}}的其他基金

Variance in sibling mothering received and adult mothering, anxiety and serotonin
兄弟姐妹养育和成人养育、焦虑和血清素的差异
  • 批准号:
    8594493
  • 财政年份:
    2013
  • 资助金额:
    $ 5.51万
  • 项目类别:

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