Imaging Core

成像核心

• 批准号: 8646971
• 负责人: AMMASI PERIASAMY
• 金额: $ 19.52万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8646971
• 关键词: Air; Antibodies; Area; Asthma; Biochemical; Biological Assay; Biology; Cell Line; Cells; Cellular Morphology; Cellular Structures; Clinical; Computer software; Confocal Microscopy; Coupled; Cystic Fibrosis; Data; Development; Dimensions; Dust; Electronics; Endothelial Cells; Environment; Epithelial Cells; Event; Fluorescence Resonance Energy Transfer; Gene Expression; Genetic Transcription; Glass; Home environment; Image; Imaging technology; Intervention; Label; Lasers; Lead; Life; Light; Location; Macromolecular Complexes; Membrane; Methodology; Methods; Microscopic; Microscopy; Neurons; Organelles; Physiological; Primary Cell Cultures; Process; Proteins; Protocols documentation; Research; Research Personnel; S-Nitrosothiols; Scanning; Second Messenger Systems; Signal Transduction; Specimen; Speed; System; Techniques; Temperature; Testing; Transduction Gene; Universities; cell type; cellular imaging; foot; imaging modality; innovation; light microscopy; molecular imaging; operation; pulmonary arterial hypertension; respiratory; second messenger; sensor; trafficking

S-nitrosylation study will lead to a potential clinical importance in the area of asthma, cystic fibrosis, and pulmonary arterial hypertension. The participating investigators require state-of-the-art imaging methodologies to demonstrate in 3- or 4-dimension of S-nitrosothiol localization and trafficking in neuronal, endothelial and epithelial cells. As outlined below the W.M. Keck Center for Cellular Imaging (KCCI) is one of the leading centers internationally in the area of advanced molecular imaging. We have the necessary space and imaging systems to implement successfully the participating investigator projects.

s -亚硝基化研究将在哮喘，囊性纤维化，