Regulation of Microtubule Dynamics

微管动力学的调节

基本信息

  • 批准号:
    8913327
  • 负责人:
  • 金额:
    $ 40.24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-03-01 至 2015-12-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Regulation of dynamic microtubules (MTs) is critical for cellular processes such as cell division, cell migration, cell polarity, organelle movements and nuclear positioning. Understanding conserved mechanisms of MT regulation are highly relevant to human biology and diseases such as cancer, neuronal diseases and wound healing. In this grant, we aim to elucidate fundamental conserved mechanisms responsible for MT regulation by studying MT plus end tracking proteins (+TIPs). These proteins coat the MT plus end and control the assembly, stability and disassembly of these polymers. In general, how these proteins work collectively to regulate MT dynamics in vivo is a pressing question in this active field. We study MT regulation using in vivo and in vitro approaches, using the fission yeast Schizosaccharomyces pombe as a tractable, simple model system. The XMAP215/Alp14 family of +TIPs is emerging as one of the most important of the +TIPs. These tubulin-binding proteins function as MT polymerases that add tubulin onto the ends of growing MT. Our preliminary results suggest that it has additional functions in MT nucleation and disassembly. Our specific aims are: 1) To define how Alp14 works with gamma tubulin complex for MT nucleation; 2) To determine how Alp14 and the kinesin-8 Klp5/6 regulate the disassembly of MTs; 3) To elucidate the molecular mechanisms of how XMAP215/Alp14 proteins interact with tubulin to regulate MT dynamics.


项目成果

期刊论文数量(0)
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专利数量(0)

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Fred Chang其他文献

Fred Chang的其他文献

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{{ truncateString('Fred Chang', 18)}}的其他基金

Mechanics of cell growth and division
细胞生长和分裂的机制
  • 批准号:
    10205904
  • 财政年份:
    2021
  • 资助金额:
    $ 40.24万
  • 项目类别:
Mechanics of cell growth and division
细胞生长和分裂的机制
  • 批准号:
    10642925
  • 财政年份:
    2021
  • 资助金额:
    $ 40.24万
  • 项目类别:
Mechanics of cell growth and division
细胞生长和分裂的机制
  • 批准号:
    10797806
  • 财政年份:
    2021
  • 资助金额:
    $ 40.24万
  • 项目类别:
Mechanics of cell growth and division
细胞生长和分裂的机制
  • 批准号:
    10431867
  • 财政年份:
    2021
  • 资助金额:
    $ 40.24万
  • 项目类别:
Regulation of Microtubule Dynamics
微管动力学的调节
  • 批准号:
    9316669
  • 财政年份:
    2015
  • 资助金额:
    $ 40.24万
  • 项目类别:
Assembly and Placement of the Cell Division Ring
细胞分裂环的组装和放置
  • 批准号:
    8000046
  • 财政年份:
    2010
  • 资助金额:
    $ 40.24万
  • 项目类别:
Microtubule Organization and Nuclear Positioning
微管组织和核定位
  • 批准号:
    8215710
  • 财政年份:
    2005
  • 资助金额:
    $ 40.24万
  • 项目类别:
Mechanisms of Nuclear Positioning and Microtubule Organization
核定位和微管组织机制
  • 批准号:
    7347593
  • 财政年份:
    2005
  • 资助金额:
    $ 40.24万
  • 项目类别:
Mechanisms of Nuclear Positioning and Microtubule Organization
核定位和微管组织机制
  • 批准号:
    7011213
  • 财政年份:
    2005
  • 资助金额:
    $ 40.24万
  • 项目类别:
Microtubule Organization and Nuclear Positioning
微管组织和核定位
  • 批准号:
    8018501
  • 财政年份:
    2005
  • 资助金额:
    $ 40.24万
  • 项目类别:

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