Mayo Clinic Metabolomics Resource Core

梅奥诊所代谢组学资源核心

• 批准号: 8916099
• 负责人: K Sreekumaran Nair
• 金额: $ 192.72万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8916099
• 关键词: Aging; Alzheimer' s Disease; American; Amino Acids; Appearance; Arizona; Basic Science; Bicarbonates; Biochemical Pathway; Bioinformatics; Biological Markers; Biostatistics Core; Carbohydrates; Cardiovascular system; Cells; Cerebrospinal Fluid; Citric Acid; Clinic; Clinical; Clinical Investigator; Clinical Research; Collaborations; Comprehensive Cancer Center; Data; Data Analyses; Diabetes Mellitus; Disease; Education; Education and Outreach; Educational Curriculum; Educational workshop; Fatty Acids; Feasibility Studies; Florida; Funding; Genomics; Glucose; Glycerol; Goals; Health; Healthcare; Human; In Vitro; Information Technology; Institution; Joints; Keto Acids; Kinetics; Label; Lipids; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Mass Spectrum Analysis; Measurement; Measures; Metabolic; Metabolic Pathway; Methodology; Methods; Minnesota; NMR Spectroscopy; Obesity; Oklahoma; Pathway interactions; Patient Care; Pharmacogenomics; Pharmacometabolomics; Physiology; Pilot Projects; Plasma; Production; Proteins; Proteomics; Protocols documentation; Recording of previous events; Recovery; Regenerative Medicine; Relative (related person); Request for Applications; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Scientist; Services; Sphingolipids; Stable Isotope Labeling; Stimulus; Structure; Techniques; Technology; Tissues; Training; Training Programs; Training and Education; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Work; amino acid metabolism; base; biomacromolecule; career development; clinical application; clinical practice; improved; in vivo; individualized medicine; innovation; instrumentation; mathematical model; metabolomics; microbiome; novel; nutrition; postdoctoral investigator; pre-doctoral; prevent; programs; response; sample collection; stable isotope; tool; translational approach

DESCRIPTION: The Mayo Clinic Comprehensive Metabolomics Research Core (MCCMRC) integrates mass spectrometry and NMR Spectroscopy to measure metabolite concentrations and their in vivo dynamics using state of the art Stable isotope techniques. In addition, we propose an outreach and education program which will support feasibility studies and provide education and training opportunities to investigators wishing to utilize these techniques. The MCCMRC will expand services over those currently provided to cater the increasing needs of investigators at a regional and national level. Our services include large scale and targeted metabolomic profiling and measurement of stable isotopes in multiple metabolites, in an integrated fashion that allows us to track changes in metabolite concentration and the underlying rates of appearance and disappearance. This will enable mapping of alterations in dynamic metabolic networking in physiology as well as in pathological states. Clinique features of our program include the use of stable isotopes in diabetes, aging, cardiovascular and lipid research as well as phospometabolomic and pharmacometabolomic approaches. The program is integrated with the Proteomic, Genomic and Pharmacogenomic centers and is supported by a common Bioinformatics/biostatistics core. In addition, we are integrated closely to the major translational research programs in Mayo Clinic including the Centers of Individualized Medicine, Regenerative Medicine, Cancer, Alzheimer, Microbiome and Aging as well as the CTSA. This allows rapid translation of the findings to clinical practice thereby improving human health and patient care. The application offers an opportunity to develop networks with other national centers offering translational approaches to metabolomic technology. We will offer analytical services as well as expertise on study design, mathematical modeling, sample collection and data analysis to institutional, regional and national investigators. MCCMRC will expand our ability to offer a visiting scientists program of workshops, short-term training and didactic courses in order to educate them on the potential of metabolomics tools for research but also on the application of these techniques to their research protocols. In addition, we will leverage institutional training and career development and develop a curriculum and hands-on training program centered on metabolic training in the participating institutions. We will also offer pilot and feasibility funds to pursue innovative approaches to research based on metabolomics. The MCCMRC has an administrative core that will coordinate and integrate all activities of the education, training and feasibility program as well as the technology cores.

描述：梅奥临床综合代谢组学研究核心(MCCMRC)集成了质谱仪和核磁共振波谱，使用最先进的稳定同位素技术测量代谢物浓度及其体内动力学。此外，我们还提出了一个外展和教育计划，该计划将支持可行性研究，并为希望利用这些技术的调查人员提供教育和培训机会。MCCMRC将在目前提供的服务基础上扩大服务，以满足区域和国家一级调查人员日益增长的需求。我们的服务包括大规模和有针对性的代谢物分析和多种代谢物中稳定同位素的测量，使我们能够跟踪代谢物浓度的变化以及潜在的出现和消失速度。这将使动态代谢网络在生理和病理状态中的变化成为可能。我们项目的临床特点包括在糖尿病、衰老、心血管和血脂研究以及磷代谢和药物代谢方法中使用稳定的同位素。该计划与蛋白质组、基因组和药物基因组学中心整合在一起，并得到一个共同的生物信息学/生物统计学核心的支持。此外，我们还与梅奥诊所的主要翻译研究项目紧密结合，包括个体化医学中心、再生医学中心、癌症中心、阿尔茨海默病中心、微生物组中心和老龄化中心以及CTSA。这使得研究结果可以迅速转化为临床实践，从而改善人类健康和病人护理。该应用程序提供了与其他国家中心发展网络的机会，这些中心提供代谢组学技术的翻译方法。我们将向机构、区域和国家调查人员提供分析服务以及研究设计、数学建模、样本收集和数据分析方面的专业知识。MCCMRC将扩大我们的能力，为访问科学家提供研讨会、短期培训和教学课程，以教育他们代谢组学工具的研究潜力，并将这些技术应用到他们的研究方案中。此外，我们将利用机构培训和职业发展，并在参与机构中制定以代谢培训为中心的课程和实践培训计划。我们还将提供试点和可行性资金，以寻求基于代谢组学的创新研究方法。MCCMRC有一个管理核心，将协调和整合教育、培训和可行性计划的所有活动以及技术核心。