Mayo Clinic Metabolomics Resource Core

梅奥诊所代谢组学资源核心

• 批准号: 9139463
• 负责人: K Sreekumaran Nair
• 金额: $ 155.09万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9139463
• 关键词: Aging; Alzheimer' s Disease; American; Amino Acids; Appearance; Arizona; Basic Science; Bicarbonates; Biochemical Pathway; Bioinformatics; Biostatistics Core; Carbohydrates; Cardiovascular system; Cells; Cerebrospinal Fluid; Citric Acid; Clinic; Clinical; Clinical Investigator; Clinical Research; Collaborations; Comprehensive Cancer Center; Data; Data Analyses; Diabetes Mellitus; Disease; Education; Education and Outreach; Educational Curriculum; Educational workshop; Fatty Acids; Feasibility Studies; Florida; Funding; Genomics; Glucose; Glycerol; Goals; Health; Healthcare; Human; In Vitro; Information Technology; Institution; Joints; Keto Acids; Kinetics; Label; Lipids; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Mass Spectrum Analysis; Measurement; Measures; Metabolic; Metabolic Pathway; Methodology; Methods; Minnesota; NMR Spectroscopy; Obesity; Oklahoma; Pathway interactions; Patient Care; Pharmacogenomics; Pharmacometabolomics; Physiology; Pilot Projects; Plasma; Production; Proteins; Proteomics; Protocols documentation; Recording of previous events; Recovery; Regenerative Medicine; Request for Applications; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Scientist; Services; Sphingolipids; Stable Isotope Labeling; Stimulus; Structure; Techniques; Technology; Tissues; Training; Training Programs; Training and Education; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Work; amino acid metabolism; base; biomacromolecule; biomarker discovery; career development; clinical application; clinical practice; improved; in vivo; individualized medicine; innovation; instrumentation; mathematical model; metabolome; metabolomics; metabolomics resource; microbiome; novel; nutrition; postdoctoral investigator; pre-doctoral; prevent; programs; response; sample collection; stable isotope; tool; training opportunity; translational approach

DESCRIPTION: The Mayo Clinic Comprehensive Metabolomics Research Core (MCCMRC) integrates mass spectrometry and NMR Spectroscopy to measure metabolite concentrations and their in vivo dynamics using state of the art Stable isotope techniques. In addition, we propose an outreach and education program which will support feasibility studies and provide education and training opportunities to investigators wishing to utilize these techniques. The MCCMRC will expand services over those currently provided to cater the increasing needs of investigators at a regional and national level. Our services include large scale and targeted metabolomic profiling and measurement of stable isotopes in multiple metabolites, in an integrated fashion that allows us to track changes in metabolite concentration and the underlying rates of appearance and disappearance. This will enable mapping of alterations in dynamic metabolic networking in physiology as well as in pathological states. Clinique features of our program include the use of stable isotopes in diabetes, aging, cardiovascular and lipid research as well as phospometabolomic and pharmacometabolomic approaches. The program is integrated with the Proteomic, Genomic and Pharmacogenomic centers and is supported by a common Bioinformatics/biostatistics core. In addition, we are integrated closely to the major translational research programs in Mayo Clinic including the Centers of Individualized Medicine, Regenerative Medicine, Cancer, Alzheimer, Microbiome and Aging as well as the CTSA. This allows rapid translation of the findings to clinical practice thereby improving human health and patient care. The application offers an opportunity to develop networks with other national centers offering translational approaches to metabolomic technology. We will offer analytical services as well as expertise on study design, mathematical modeling, sample collection and data analysis to institutional, regional and national investigators. MCCMRC will expand our ability to offer a visiting scientists program of workshops, short-term training and didactic courses in order to educate them on the potential of metabolomics tools for research but also on the application of these techniques to their research protocols. In addition, we will leverage institutional training and career development and develop a curriculum and hands-on training program centered on metabolic training in the participating institutions. We will also offer pilot and feasibility funds to pursue innovative approaches to research based on metabolomics. The MCCMRC has an administrative core that will coordinate and integrate all activities of the education, training and feasibility program as well as the technology cores.

描述：Mayo诊所综合代谢组学研究核心（MCCMRC）使用稳定的同位素技术的状态整合质谱和NMR光谱，以测量代谢物浓度及其体内动力学。此外，我们提出了一项宣传和教育计划，该计划将支持可行性研究，并向希望利用这些技术的调查人员提供教育和培训机会。 MCCMRC将扩大服务的服务，而不是目前提供的服务，以满足区域和国家一级的调查人员需求。我们的服务包括大规模和靶向代谢组分析以及多种代谢物中稳定同位素的测量，以综合方式，使我们能够跟踪代谢物浓度的变化以及外观和消失的基本速率。这将使生理和病理状态中动态代谢网络的变化映射。我们计划的临床特征包括在糖尿病中使用稳定的同位素，衰老，心血管和脂质研究以及凤凰代谢组和药物素代谢组学方法。该程序与蛋白质组学，基因组和药物基因组中心集成在一起，并由常见的生物信息学/生物统计学核心支持。此外，我们与Mayo诊所的主要转化研究计划紧密整合，包括个性化医学，再生医学，癌症，阿尔茨海默氏症，微生物组和衰老中心以及CTSA。这允许将发现快速转化为临床实践，从而改善了人类健康和患者护理。该应用程序提供了与其他国家中心开发网络的机会，该中心提供了代谢组技术的转化方法。我们将向机构，区域和国家研究人员提供分析服务以及研究设计，数学建模，样本收集和数据分析的专业知识。 MCCMRC将扩大我们提供访问科学家的讲习班，短期培训和教学课程的能力，以教育他们的代谢组学工具进行研究的潜力，还可以将这些技术应用于其研究方案。此外，我们将利用机构培训和职业发展，并制定以参与机构的代谢培训为中心的课程和动手培训计划。我们还将提供试点和可行性资金，以基于代谢组学进行创新的研究方法。 MCCMRC具有行政核心，该核心将协调和整合教育，培训和可行性计划的所有活动以及技术核心。