Iron Metabolism and Liver Disease

铁代谢与肝病

• 批准号: nhmrc : 339400
• 负责人: E/Pr Lawrie Powell
• 金额: $ 219.07万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/iron-metabolism-liver-disease/96315
• 关键词: Iron; Metabolism; Liver; Disease

The Chief Investigators have worked as a team for 20 years as part of a successful NHMRC Program Grant that was renewed on three successive occasions and subsequently under a NHMRC Block Grant to QIMR. Their combined expertise covers the whole spectrum from the bedside to the bench with respect to clinical studies and fundamental molecular studies of iron homeostasis. The common theme of iron homeostasis and iron overload pervades virtually all the research of the team. The team�s research has led to fundamental observations of iron regulation and homeostasis and the development of guidelines for the management of, and screening for, haemochromatosis, recognized as the most common inherited disorder of Caucasian populations. The proposed research encompasses molecular studies aimed at deciphering the mechanisms of iron absorption and transport; how these processes are regulated; and clinical studies on patients diagnosed with haemochromatosis. The findings are particularly pertinent to the diagnosis, management and prevention of clinical haemochromatosis.

首席调查员作为一个团队工作了20年，作为成功的NHMRC计划赠款的一部分，该计划赠款连续三次续签，随后根据NHMRC对QIMR的整体赠款。他们的专业知识涵盖了从床边到实验室的整个范围，涉及铁稳态的临床研究和基础分子研究。铁稳态和铁过载的共同主题几乎贯穿了该团队的所有研究。该团队的研究导致了对铁调节和稳态的基本观察，并制定了管理和筛查血色病的指南，血色病被认为是高加索人群中最常见的遗传性疾病。拟议的研究包括旨在破译铁吸收和转运机制的分子研究;这些过程是如何调节的;以及对被诊断患有血色病的患者的临床研究。这些发现对临床血色病的诊断、治疗和预防特别重要。