Temple University Gastroparesis Clinical Center

天普大学胃轻瘫临床中心

基本信息

  • 批准号:
    8730610
  • 负责人:
  • 金额:
    $ 36.53万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-04-15 至 2016-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Patients with gastroparesis often suffer with chronic gastrointestinal symptoms that are not adequately treated due to both a lack of understanding of the underlying pathophysiology and lack of effective treatments. The participation of Temple University in the NIH/NIDDK Gastroparesis Clinical Research Consortium and the proposed studies will help achieve the broad, long term objectives of improving the diagnosis and treatment of patients with gastroparesis. The PI and Temple University are exceptionally well qualified to continue to be one of the clinical centers in this consortium. Temple University has clinical expertise and an active research program in the evaluation and treatment of patients with gastroparesis. The aims for this renewal of the Gastroparesis Consortium are threefold. First, to complete the ongoing and approved studies initiated by the GpCRC. These studies include NORIG: a randomized trial of nortriptyline vs. placebo for idiopathic gastroparesis; GLUMIT-DG: a pilot study of safety, feasibility and potential efficacy of continuous glucose monitoring and insulin pump therapy in diabetic gastroparesis; APRON: a randomized trial of aprepitant vs. placebo for the relief of nausea in patients with chronic nausea and vomiting of presumed gastric origin; PBG: pathological basis of gastroparesis, a tissue study from full thickness gastric biopsies. Second, to maintain and expand the Gastroparesis Registry. Our aim is to have at least four years of follow-up on patients and with up to nine years for some patients. This will require maintenance of the Registry and continued periodic follow-up visits over the next five years. In addition, we propose recruitment of new patients during continuation of the Gastroparesis Consortium with refinements to existing questionnaires and pathophysiologic measures, as well as new ones. This will allow us to answer questions related to the pathogenesis, severity grading, complications, treatment responses, and clinical outcomes in patients with gastroparesis. Third, to conduct new multicenter studies of gastroparesis investigating the etiology, pathogenesis, diagnosis, and treatment. The PI with his collaborators at Temple University propose a multicenter study aimed at improving the diagnosis of gastric motility disorders. The overall purpose of this project is to develop a single more comprehensive noninvasive test which evaluates several components of gastric motility and, thus, may improve the correlation between dyspeptic symptoms and gastric dysmotility. This will ultimately enable physicians to better target therapy to the underlying gastric pathophysiologic abnormality in patients with gastroparesis.
描述(申请人提供):胃瘫患者通常患有慢性胃肠道症状,由于缺乏对基本病理生理学的了解和缺乏有效的治疗,这些症状没有得到充分的治疗。坦普尔大学参与NIH/NIDDK胃瘫临床研究联盟和拟议的研究将有助于实现改善胃瘫患者诊断和治疗的广泛、长期目标。PI和坦普尔大学非常有资格继续成为该联盟的临床中心之一。坦普尔大学在评估和治疗胃瘫患者方面拥有临床专业知识和积极的研究计划。这次胃瘫联盟的更新有三个目标。第一,完成GpCRC正在进行的和已获批准的研究。这些研究包括:NORIG:去甲替林与安慰剂治疗特发性胃轻瘫的随机试验;GLUMIT-DG:持续血糖监测和胰岛素泵治疗糖尿病胃轻瘫的安全性、可行性和潜在疗效的试点研究;APRON:APRAPANT与安慰剂治疗慢性恶心和疑似胃源性呕吐患者的随机试验;PBG:胃瘫的病理基础,这是一项来自全层胃活检的组织研究。第二,维护和扩大胃瘫登记处。我们的目标是对患者进行至少四年的随访,有些患者的随访时间长达九年。这将需要维持书记官处,并在今后五年内继续定期进行后续访问。此外,我们建议在胃瘫协会继续治疗期间招募新的患者,改进现有的问卷和病理生理指标,以及新的调查问卷。这将使我们能够回答与胃瘫患者的发病机制、严重程度分级、并发症、治疗反应和临床结果有关的问题。第三,对胃轻瘫进行新的多中心研究,探讨其病因、发病机制、诊断和治疗。PI和他在坦普尔大学的合作者提出了一项旨在改善胃动力障碍诊断的多中心研究。该项目的总体目的是开发一种单一的、更全面的非侵入性测试,评估胃动力的几个组成部分,从而可能改善消化不良症状和胃动力障碍之间的相关性。这最终将使医生能够更好地针对胃瘫患者潜在的胃病理生理异常进行靶向治疗。

项目成果

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HENRY PAUL PARKMAN其他文献

HENRY PAUL PARKMAN的其他文献

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{{ truncateString('HENRY PAUL PARKMAN', 18)}}的其他基金

Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    7905310
  • 财政年份:
    2009
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    7872908
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    7032010
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    8114478
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University's Center for Clinical Research and Translational Sciences
天普大学临床研究和转化科学中心
  • 批准号:
    7216471
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Effects of COVID-19 in Patients with Gastroparesis: A GpCRC Supplement
COVID-19 对胃轻瘫患者的影响:GpCRC 补充剂
  • 批准号:
    10179037
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    8545578
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    7616832
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    8327158
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:
Temple University Gastroparesis Clinical Center
天普大学胃轻瘫临床中心
  • 批准号:
    9357609
  • 财政年份:
    2006
  • 资助金额:
    $ 36.53万
  • 项目类别:

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