Iron overload mechanisms in dyserythropoietic anaemias and therapeutic targets at the ERFE gene locus

红细胞生成障碍性贫血的铁过载机制和 ERFE 基因位点的治疗靶点

• 批准号: nhmrc : 2005394
• 金额: $ 13.27万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/iron-overload-mechanisms-gene-locus/1780581
• 关键词: Iron; overload; mechanisms; dyserythropoietic; anaemias

Iron overload causes organ dysfunction and morbidity for people who have red blood cell disorders such as thalassemia, or chronic transfusion requirements due to cancer or bone marrow failure. The manner in which a principal controlling compound, erythroferrone, influences iron metabolism is undefined. Our project will use molecular approaches to determine how the erythroferrone gene is involved in causing iron overload in red cell disorders and potentially open better management pathways.

铁超载会导致器官功能障碍和患有地中海贫血等红细胞疾病或因癌症或骨髓衰竭而需要长期输血的人的发病率。主要控制化合物红铁酮影响铁代谢的方式尚不清楚。我们的项目将使用分子方法来确定红细胞铁素基因是如何参与导致红细胞疾病中的铁超载的，并可能开辟更好的管理途径。