NINDS Biomarker Repository

 描述（由申请人提供）：我们提出了一种NINDS人类生物标志物生物样本和数据储存库的综合方法，该方法将满足RFA-NS-15-010中列出的所有要求。印第安纳州大学目前拥有阿尔茨海默病、帕金森病和脑震荡研究领域的关键知识库。我们已经建立了一个强大的行政结构，确保生物储存库功能的各个方面得到良好的设计和维护。所有流程都由标准操作程序驱动，确保各级的一致性。我们将以我们成功的生物储存经验为基础，与NINDS资助的所有团体以及合作伙伴组织建立强有力的合作伙伴关系。这将确保为NINDS生物标志物储存库开发一种全面的生物库方法，使样本能够满足未来研究的需要。我们有能力协调多个相关生物库的需求，这一努力的成功将最大限度地提高 就在印第安纳州大学。基于我们过去在建立广泛使用的生物标本库方面的成功，我们建议在NINDS和科学联络委员会的监督下，实现以下具体目标：目标1：建立一个强大的行政结构，监督NINDS生物标志物库的各个方面。目标2：创建和维护一个最先进的生物样本库，用于接收、处理和存储来自已批准研究的所有样本。目标3：协调NINDS生物标志物生物储存库的所有数据管理和网络活动。

 DESCRIPTION (provided by applicant): We propose a comprehensive approach to the NINDS Human Biomarkers Biospecimen and Data Repository that will fulfill all requirements listed in RFA-NS-15-010. Indiana University currently houses key repositories in the areas of Alzheimer's disease, Parkinson's disease and concussion research. We have developed a strong administrative structure that ensures that all aspects of biorepository function are well designed and maintained. All processes are driven by standard operating procedures, ensuring uniformity at all levels. We will build on our successful biorepository experience to create a strong partnership with all groups funded by NINDS as well as partner organizations. This will ensure that a comprehensive approach to biobanking is developed for the NINDS Biomarker Repository that will allow samples to meet the needs of future research. The success of this effort will be maximized by our ability to coordinate the needs of multiple related biorepositories housed here at Indiana University. Based on our past success in establishing widely used biospecimen repositories, we propose under the oversight of NINDS and the Scientific Liaison Committee, the following specific aims: Aim 1: Establish a strong administrative structure that will oversee all aspects of the NINDS Biomarker Repository. Aim 2: Create and maintain a state-of-the-art biospecimen repository that receives processes and stores all samples from approved studies. Aim 3: Coordinate all data management and web-based activities of the NINDS Biomarker Biorepository.