Biospecimen Exchange for Neurological Disorders (BioSEND)

神经系统疾病生物样本交换 (BioSEND)

• 批准号: 10674941
• 负责人: TATIANA M. FOROUD
• 金额: $ 186.52万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674941
• 关键词: Aliquot; Award; Basic Science; Biological Markers; Biological Specimen Banks; Blinded; Catalogs; Cerebrospinal Fluid; Chronic Fatigue Syndrome; Clinical Data; Clinical Research; Communities; Custom; DNA; Data; Data Coordinating Center; Dementia with Lewy Bodies; Disease; Ensure; Epilepsy; Faculty; Frontotemporal Dementia; Funding; Genetic; Growth; Human; Huntington Disease; Indiana; Infrastructure; Institution; Laboratories; Leadership; Lewy Body Dementia; Link; Medical Research; Mission; Names; National Institute of Neurological Disorders and Stroke; Parkinson Disease; Peripheral Blood Mononuclear Cell; Plasma; Protocols documentation; Quality Control; RNA; Research; Research Personnel; Research Subjects; Resources; Saliva; Sampling; Sampling Studies; Science; Secure; Serum; Site; Spinocerebellar Ataxias; Time; Training; Translational Research; Traumatic Brain Injury; Universities; Urine; Work; biobank; data management; data repository; data sharing; experience; improved; innovation; material transfer agreement; nervous system disorder; quality assurance; repository; response; success; vascular cognitive impairment and dementia; web site

PROJECT SUMMARY/ABSTRACT We have prepared this application in response to RFA-NS-20-031, which invites applicants to serve as the NINDS Human Biospecimen and Data Repository in Neurological Disorders. The BioSpecimen Exchange for Neurological Disorders (BioSEND) was awarded to Indiana University on September 30, 2015. This application proposes to renew and retain BioSEND at Indiana University and expand the impact and success of BioSEND through additional innovations and improvements. With the transfer of the NINDS-funded biorepository to Indiana University, BioSEND dramatically expanded the number of disorders for which samples are banked. The scope and scale of banking has also dramatically increased with the establishment of BioSEND at Indiana University. The value of the biospecimens banked at BioSEND is demonstrated by the substantial growth in the requests for these samples by researchers. Over the past five years, BioSEND has made 93 distributions to 42 investigators at more than 30 institutions. Indiana University has developed a strong biorepository team consisting of faculty with critical scientific and leadership experience and staff with essential expertise in biobanking, clinical research coordination, and data management. Over the past five years, we have developed a strong infrastructure and implemented a customer- focused approach that employs innovative solutions to both specimen banking and distribution. Based on our success in establishing a widely used biospecimen repository, we plan further improvements and expansion of BioSEND to meet the NINDS mission to increase biobanking to support basic, translational and clinical research in neurological disorders. We propose to pursue the following specific aims for the next five years: Aim 1: Provide leadership to BioSEND Aim 2: Provide study management expertise Aim 3: Provide scientific and laboratory expertise Aim 4: Distribute samples to approved researchers Aim 5: Develop custom solutions to link clinical data with biospecimens

项目总结/摘要 我们已经准备了这个应用程序响应RFA-NS-20-031，邀请申请人担任 NINDS人类生物标本和神经疾病数据库。生物样本交换 神经系统疾病（BioSEND）于2015年9月30日授予印第安纳州大学。本申请 建议在印第安纳州大学更新和保留BioSEND，并扩大BioSEND的影响和成功 通过更多的创新和改进。 随着NINDS资助的生物储存库转移到印第安纳州大学，BioSEND急剧扩大 存储样本的疾病数量。银行业的范围和规模也急剧扩大， 随着印第安纳州大学BioSEND的建立而增加。生物样本的价值 研究人员对这些样本的要求大幅增长，证明了BioSEND。来 在过去的五年里，BioSEND已经向30多个机构的42名研究人员分发了93份。 印第安纳州大学已经建立了一个强大的生物贮藏库团队，由具有关键科学和 具有领导经验和生物库、临床研究协调和数据方面的基本专业知识的工作人员 管理在过去的五年里，我们开发了强大的基础设施，并实施了客户- 采用创新的解决方案来进行样本库和分销。基于我们 在成功建立一个广泛使用的生物标本储存库后，我们计划进一步改善和扩大 BioSEND将满足NINDS的使命，即增加生物库，以支持基础、转化和临床研究 神经系统疾病我们建议在今后五年实现以下具体目标： 目标1：领导BioSEND 目标2：提供研究管理专业知识 目标3：提供科学和实验室专门知识 目标4：将样本分发给经批准的研究人员 目标5：开发定制解决方案，将临床数据与生物标本联系起来

项目成果

Long-read sequencing resolves a complex structural variant in PRKN Parkinson's disease.

长读长测序解决了 PRKN 帕金森病的复杂结构变异。

• DOI: 10.1101/2023.08.14.23293948
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Daida,Kensuke;Funayama,Manabu;Billingsley,KimberleyJ;Malik,Laksh;Miano-Burkhardt,Abigail;Leonard,HamptonL;Makarious,MaryB;Iwaki,Hirotaka;Ding,Jinhui;Gibbs,JRaphael;Ishiguro,Mayu;Yoshino,Hiroyo;Ogaki,Kotaro;Oyama,Genko;Nishi
• 通讯作者: Nishi

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.

• DOI: 10.1002/mds.28549
• 发表时间: 2021-08
• 期刊: Movement disorders : official journal of the Movement Disorder Society
• 作者: Iwaki H;Leonard HL;Makarious MB;Bookman M;Landin B;Vismer D;Casey B;Gibbs JR;Hernandez DG;Blauwendraat C;Vitale D;Song Y;Kumar D;Dalgard CL;Sadeghi M;Dong X;Misquitta L;Scholz SW;Scherzer CR;Nalls MA;Biswas S;Singleton AB;Uniformed Services University of the Health Sciences Associates;AMP PD Whole Genome Sequencing Working Group;AMP PD consortium
• 通讯作者: AMP PD consortium

Prediction of DNA binding proteins using local features and long-term dependencies with primary sequences based on deep learning.

• DOI: 10.7717/peerj.11262
• 发表时间: 2021
• 期刊: PeerJ
• 影响因子: 2.7
• 作者: Li G;Du X;Li X;Zou L;Zhang G;Wu Z
• 通讯作者: Wu Z

Multi-modality machine learning predicting Parkinson's disease.

• DOI: 10.1038/s41531-022-00288-w
• 发表时间: 2022-04-01
• 期刊: NPJ Parkinson's disease
• 作者: Makarious MB;Leonard HL;Vitale D;Iwaki H;Sargent L;Dadu A;Violich I;Hutchins E;Saffo D;Bandres-Ciga S;Kim JJ;Song Y;Maleknia M;Bookman M;Nojopranoto W;Campbell RH;Hashemi SH;Botia JA;Carter JF;Craig DW;Van Keuren-Jensen K;Morris HR;Hardy JA;Blauwendraat C;Singleton AB;Faghri F;Nalls MA
• 通讯作者: Nalls MA

The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.

生活方式因素和多基因评分对帕金森病发病年龄的综合影响。

• DOI: 10.1101/2023.08.25.23294466
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Gabbert,Carolin;Blöbaum,Leonie;Lüth,Theresa;König,InkeR;Caliebe,Amke;Koch,Sebastian;Björn-Hergen,Laabs;Klein,Christine;Trinh,Joanne
• 通讯作者: Trinh,Joanne