Iron and Oxidative Stress in Stable and Unstable Coronary Artery Disease

稳定和不稳定冠状动脉疾病中的铁和氧化应激

• 批准号: nhmrc : 526697
• 负责人: Dr William Chan
• 金额: $ 5.77万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/iron-oxidative-stress-artery-disease/115826
• 关键词: Iron; Oxidative; Stress; Stable; Unstable

This PhD investigates the key roles iron and insufficient antioxidants play in worsening tissue injury during and following a heart attack, in precipitating blockages in heart arteries, and in impairing blood vessel function in those with heart disease. By using drugs to remove iron from the body, it is possible to compare the detrimental effects of iron (on tissue injury and blood vessel function) in the group treated with the medication and the group treated with placebo.

该博士研究了铁和抗氧化剂不足在心脏病发作期间和之后恶化组织损伤、导致心脏动脉阻塞以及心脏病患者血管功能受损方面所起的关键作用。通过使用药物从体内去除铁，可以比较接受药物治疗的组和接受安慰剂治疗的组中铁的有害影响(对组织损伤和血管功能)。