Assessment of microcirculatory impairment in reperfused acute myocardial infarction by invasive coronary hemodynamic measurements and cardiac magnetic resonance imaging: modulation by exenatide

通过侵入性冠状动脉血流动力学测量和心脏磁共振成像评估再灌注急性心肌梗死的微循环障碍：艾塞那肽的调节

• 批准号: nhmrc : 1052960
• 负责人: Dr William Chan
• 金额: $ 25.92万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assessment-microcirculatory-impairment-modulation-exenatide/112304
• 关键词: Assessment; microcirculatory; impairment; reperfused; acute

This study aims to assess the health of small blood vessels of the heart muscle during and following a heart attack by measuring blood flow with a pressure wire and with cardiac magnetic resonance imaging. Small blood vessels within the heart muscle may become injured due to lack of oxygen and white cell activation during a heart attack. This study investigates the effect of a new agent, exenatide, on small blood vessels and white cells and determines whether it might lessen the degree of damage to heart muscle and small blood vessels.

本研究旨在通过使用压力导丝和心脏磁共振成像测量血流，评估心脏病发作期间和之后心肌小血管的健康状况。心肌内的小血管在心脏病发作期间可能由于缺氧和白色细胞激活而受伤。这项研究调查了一种新的药物艾塞那肽对小血管和白色细胞的影响，并确定它是否可能减轻对心肌和小血管的损伤程度。