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Genetic and epigenetic controls of gene regulation

Genetic and epigenetic controls of gene regulation
基因调控的遗传和表观遗传控制
批准号：
8701329
负责人：
JONATHAN K PRITCHARD
金额：
$38.67万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-09-17 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8701329
关键词：
Active SitesAffectArchitectureBase PairingBase SequenceBindingBiologicalBiological AssayChromatinCommunitiesComplexComputing MethodologiesDNA MethylationDNA SequenceDataData AnalysesData SetDiseaseElementsEpigenetic ProcessGene ExpressionGene Expression RegulationGeneticGenetic VariationGenomicsHistonesIndividualMessenger RNAMethodsModelingNucleic Acid Regulatory SequencesNucleosomesOrganismOutputPaperPhenotypePlayPositioning AttributeProteinsPublishingRegulator GenesRegulatory ElementReporter GenesResearch PersonnelResolutionRoleScientistSignal TransductionSiteStatistical MethodsStatistical ModelsTechnologyTestingTissuesValidationVariantWorkanalytical toolcell typecomputerized toolsexperiencegenome wide association studygenome-widehistone modificationimprovedinsighttranscription factor

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DESCRIPTION (provided by applicant): We propose to develop statistical and computational methods for interpreting data on gene regulation in a variety of cell types from the ENCODE Project. Our work will focus on (i) developing methods for integrating diverse data types in many tissues to infer chromatin architecture; (ii) inferring the sequence determinants and regulatory consequences of differences in chromatin across cell types; and (iii) empirical tests of our predictions using both natural genetic variation and experimental approaches.
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