Isolation and characterisation of novel progenitor cells in the mammary epithelium and their role during carcinogenesis.

乳腺上皮中新型祖细胞的分离和表征及其在癌发生过程中的作用。

• 批准号: nhmrc : 516792
• 负责人: Dr Samantha Oakes
• 金额: $ 31.36万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/isolation-characterisation-novel-role-carcinogenesis/115692
• 关键词: Isolation; characterisation; novel; progenitor; cells

Stem and progenitor cells in the breast are the immature cells from which mature cells are derived. Their are long-lived, resistant to death and can produce multiple types of mature cells, implicating them as cells from which breast cancer may originate. We aim to search for novel cell surface markers that define the progenitor cells in the mouse mammary gland. The data gathered from this project may facilitate the development of targeted therapies to the cells of origin in breast cancer.

乳腺中的干细胞和祖细胞是由成熟细胞衍生而来的未成熟细胞。它们寿命长，对死亡有抵抗力，可以产生多种类型的成熟细胞，这意味着它们可能是乳腺癌的起源细胞。我们的目的是在小鼠乳腺中寻找新的细胞表面标记物来定义祖细胞。从这个项目中收集的数据可能会促进针对乳腺癌起源细胞的靶向治疗的发展。