Isolation and characterisation of novel progenitor cells in the mammary epithelium and their role during carcinogenesis.

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Stem and progenitor cells in the breast are the immature cells from which mature cells are derived. Their are long-lived, resistant to death and can produce multiple types of mature cells, implicating them as cells from which breast cancer may originate. We aim to search for novel cell surface markers that define the progenitor cells in the mouse mammary gland. The data gathered from this project may facilitate the development of targeted therapies to the cells of origin in breast cancer.