DOCTR Resource Center Planning

 描述(由申请者提供)：加州大学洛杉矶分校、斯坦福大学和全国各地的研究人员取得的许多基本发现导致了干细胞、生长因子、药物输送载体和生物活性支架材料方面的新技术。尽管取得了巨大的进步，但很少有发现能够推进到FDA批准的组织工程产品。此外，几乎没有生物测试和动物模型可用于可靠地验证组织再生产品的安全性和有效性。这种差异是由于臭名昭著的“死亡之谷”，它将令人惊叹的科学与患者的利益分开。加州大学洛杉矶分校-斯坦福大学牙科口腔颅面组织再生中心(UCLA-Stanford DOCTRC)是一个公私联合体，主要使命是提供科学、技术、法规、财务和管理资源，促进牙科口腔颅面组织再生产品的经济高效过渡和及时开发。在第一阶段规划阶段，将举行4次季度会议和9次月度工作会议，以1)发展组织结构，利用现有资源，确定未得到满足的资源需求；以及2)发展跨学科转换项目团队，以建立领先的和流水线DOC组织再生产品。

 DESCRIPTION (provided by applicant): Many basic discoveries made by researchers at UCLA, Stanford, and across the nation have led to novel technologies in stem cells, growth factors, drug delivery carriers, and bioactive scaffolding materials. Despite this tremendous progress, very few discoveries manage to advance to FDA approved tissue engineering products. Furthermore, few bioassays and animal models are available for reliable validation of safety and efficacy for the tissue regeneration products. This discrepancy is due to the infamous "Valley of Death" that separates amazing science from patient benefits. The interdisciplinary UCLA-Stanford Dental Oral Craniofacial Tissue Regeneration Center (UCLA-Stanford DOCTRC) is a public-private consortium with the primary mission of providing scientific, technical, regulatory, financial, and management resources to promote cost-effective transition and timely development of dental oral craniofacial tissue regeneration products. During this Stage 1 planning phase, 4 quarterly conferences and und 9 monthly working meetings will be held to 1) develop organizational structure, leverage existing resources, identify unmet resource needs; and 2) Develop Interdisciplinary Translational Project teams to build lead and pipeline DOC tissue regeneration products.