G-CSF prevents male infertility after chemotherapy.

G-CSF 可预防化疗后男性不育症。

• 批准号: 8839268
• 负责人: Brian Peter Hermann
• 金额: $ 16.86万
• 依托单位: UNIVERSITY OF TEXAS SAN ANTONIO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-16 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8839268
• 关键词: Address; Adverse effects; Anesthesia procedures; Antineoplastic Agents; Biological Preservation; Biopsy; Bone Marrow Transplantation; Busulfan; CSF3 gene; CSF3R gene; Cancer Survivor; Childhood Cancer Treatment; Clinic; Clinical; Development; Dose; FDA approved; Fertility; Filgrastim; Future; Germ Cells; Granulocyte Colony-Stimulating Factor; Granulocyte Colony-Stimulating Factor Receptors; Health; Injection of therapeutic agent; Intervention; Macaca mulatta; Male Infertility; Malignant Neoplasms; Mediating; Modeling; Mus; Natural regeneration; Operative Surgical Procedures; Patients; Pharmaceutical Preparations; Production; Quality of life; Radiation; Recovery; Regimen; Research; Retrieval; Risk; Route; Sampling; Seminal fluid; Spermatogenesis; Spermatogonia; Staging; Stem cell transplant; Stem cells; Techniques; Testicular Tissue; Testing; Testis; Tissue Grafts; Tissue Harvesting; Tissues; Translating; Translations; Treatment Protocols; adult stem cell; base; cancer cell; cancer therapy; cellular targeting; chemotherapy; cryogenics; cytokine; cytotoxicity; improved; innovation; male; nonhuman primate; novel strategies; postnatal; prevent; protective effect; research study

DESCRIPTION (provided by applicant): Spermatogonial stem cells (SSCs) are adult stem cells in mammalian testes that maintain spermatogenesis and are essential for male fertility. Male infertility resulting from SSC loss after cancer treatments (e.g., chemotherapy and radiation) is a quality-of-life issue for many cancer survivors. In this proposal, we will test a nvel approach to preserving male fertility after cancer treatment that employs injections of the cytokine granulocyte colony-stimulating factor (G-CSF). In Aim 1, we will confirm that G-CSF administration prevents loss of spermatogenesis and fertility after chemotherapy and determine the optimal treatment regimen to maximize these beneficial effects. In Aim 2, we will determine whether G-CSF treatments act at the level of SSCs and will begin to address its protective mechanism of action. If found to be effective, G-CSF treatment would completely obviate the need for risky invasive interventions, and thus, has the potential to significantly improve the clinical paradigm for preserving male fertility after cancer treatment.

描述（由申请方提供）：精原干细胞（SSC）是哺乳动物睾丸中维持精子发生的成体干细胞，对男性生育力至关重要。癌症治疗后SSC损失导致的男性不育症（例如，化疗和放疗）是许多癌症幸存者的生活质量问题。在这个建议中，我们将测试一种新的方法，以保持男性生育能力后，癌症治疗，采用注射细胞因子粒细胞集落刺激因子（G-CSF）。在目标1中，我们将证实G-CSF给药可预防化疗后精子发生和生育能力的丧失，并确定最佳治疗方案，以最大限度地发挥这些有益作用。在目标2中，我们将确定G-CSF治疗是否在SSC水平起作用，并将开始探讨其保护作用机制。如果发现有效，G-CSF治疗将完全消除对危险的侵入性干预的需要，因此，有可能显着改善癌症治疗后保留男性生育能力的临床范例。