临床基因组学和实验治疗学-猫眼课题宝

临床基因组学和实验治疗学

批准号：

9155431

负责人：

Falk Lohoff

金额：

$301.04万

依托单位：

NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/9155431

关键词：

Affect Affective Anxiety Disorders Area Biological Markers Clinical Clinical Research DNA Sequence Dopamine Emotions Epigenetic Process Fright Functional Imaging Functional disorder Genetic Genomics Genotype Human Individual Differences Intervention Methods Molecular Neurobiology Neurons Other Genetics Pharmacogenetics Pharmacological Treatment Phase Post-Traumatic Stress Disorders Process Proteomics RNA Sequences Regulation Research Risk Signal Transduction Subgroup Therapeutic Translating Treatment outcome Work addiction alcohol use disorder base dopamine transporter emotion regulation genetic approach genome-wide human population genetics interest neurobiological mechanism next generation novel therapeutics pre-clinical precision medicine preclinical study problem drinker research study transcriptome sequencing treatment response

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英文摘要

Section on Clinical Genomics and Experimental Therapeutics (SCGET) 1. Conducts pre-clinical studies and translational clinical studies with focus on genomics and epigenetics related to the pathophysiology and treatment of alcohol use disorders and addictions. 2. Pre-clinical work focuses on identifying molecular mechanisms involved in addictions, utilizing a wide array of methods including human population genetics, genome wide genotyping approaches, next-generation DNA and RNA sequencing, and epigenetic/proteomic profiling. 3. Findings are translated into human clinical studies using molecular biomarker, pharmacogenetic, epigenetic and functional imaging genetic approaches. 4. Clinical studies include early phase 1 / phase 2 proof-of-concept studies of experimental novel therapeutics guided by molecular biomarker profiling.

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