Clinical Genomics and Experimental Therapeutics

临床基因组学与实验治疗学部(SCGET) 1.开展以基因组学为重点的临床前研究和转化性临床研究 以及与酒精使用障碍的病理生理学和治疗相关的表观遗传学 上瘾。 2.临床前工作侧重于确定与成瘾有关的分子机制， 利用广泛的方法，包括人类群体遗传学，全基因组 基因分型方法、下一代DNA和RNA测序以及 表观遗传学/蛋白质组学。 3.使用分子生物标记物将发现转化为人类临床研究， 药物遗传学、表观遗传学和功能成像遗传学方法。 4.临床研究包括早期阶段1/阶段2实验性概念验证研究 分子生物标志物图谱指导的新疗法。

Section on Clinical Genomics and Experimental Therapeutics (SCGET) 1. Conducts pre-clinical studies and translational clinical studies with focus on genomics and epigenetics related to the pathophysiology and treatment of alcohol use disorders and addictions. 2. Pre-clinical work focuses on identifying molecular mechanisms involved in addictions, utilizing a wide array of methods including human population genetics, genome wide genotyping approaches, next-generation DNA and RNA sequencing, and epigenetic/proteomic profiling. 3. Findings are translated into human clinical studies using molecular biomarker, pharmacogenetic, epigenetic and functional imaging genetic approaches. 4. Clinical studies include early phase 1 / phase 2 proof-of-concept studies of experimental novel therapeutics guided by molecular biomarker profiling.