Structural and functional brain magnetic resonance imaging findings of chemothera

描述（由申请人提供）：乳腺癌是美国女性中诊断出的主要癌症，也是癌症死亡的第二大原因。辅助化疗已被证明可以降低乳腺癌复发和死亡率的风险。然而，老年人化疗毒性的风险增加，包括治疗相关死亡率的风险增加。目前，只有初步的证据表明乳腺癌患者的大脑结构和功能受到化疗和毒性的影响。然而，这项先前的研究并没有专门研究老年妇女。因此，有必要建立一种具有可重复生物标志物的更敏感的测试，以识别化疗毒性风险较高的老年乳腺癌患者。我们的长期目标是识别与老年癌症患者化疗毒性相关的高灵敏度和可重复的脑MRI生物标志物。为了实现这一目标，本研究的目的是确定脑MRI上发生的变化并确定脑MRI变化与老年乳腺癌患者化疗毒性之间的关系。我们的目标是：1)确定老年乳腺癌患者接受辅助化疗时脑MRI上发生的结构和功能变化；2)确定脑MRI结构和功能改变的严重程度与化疗毒性的关系。我们期望在我们的患者的大脑MRI结构和功能变化的严重程度将

DESCRIPTION (provided by applicant): Breast cancer is the leading cancer diagnosed among woman in the US and is the second leading cause of cancer deaths. Adjuvant chemotherapy has been proven to decrease the risks of relapse and mortality from breast cancer. However, older adults are at increased risk for chemotherapy toxicity, including an increased risk of treatment-related mortality. At present, there is only preliminary evidence regarding which brain structures and functions are affected by chemotherapy and toxicity in breast cancer patients. However, this prior research did not specifically study older women. Thus, there is a need to establish a more sensitive test that has reproducible biomarkers, to identify the older breast cancer patients who are at higher risk for chemotherapy toxicity Our long term goal is to identify highly sensitive and reproducible brain MRI biomarkers that are associated with chemotherapy toxicity in aging cancer patients. Toward that goal, the objective of this study is to define the changes that occur on brain MRI and to determine the relationship between brain MRI changes and chemotherapy toxicity in older adults with breast cancer. We aim to 1) define structural and functional changes that occur on brain MRI of older women with breast cancer receiving adjuvant chemotherapy and; 2) determine the relationship between the severity of structural and functional changes on brain MRI and chemotherapy toxicity. We expect that the severity of structural and functional changes to the brain MRI in our patients will correlate with the severity of chemotherapy toxicity. The proposed study is significant because it focuses on the unknown relationship between brain MRI changes and chemotherapy toxicity in older women with breast cancer. It is innovative because it proposes advanced MRI techniques to study and identify the novel potential biomarkers for chemotherapy toxicity in older adults with breast cancer. It will have a positive impact by helping to clarify the underlying pathophysiology of cognitive decline caused by chemotherapy toxicity. The data generated from this pilot study will also help to serve as a foundation for future large scale studies of cognition and chemotherapy in older adults.